| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | BCL-6 corepressor, BCoR, BCOR, KIAA1575 |
| Entrez GeneID | 54880 |
| WB Predicted band size | 192.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This BCOR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1107-1137 amino acids from the Central region of human BCOR. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下是3条与BCOR(Center S1122)抗体相关的参考文献及其摘要概括：
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1. **文献名称**: "BCOR alterations in myeloid neoplasms: clinicopathologic and molecular characterization"
**作者**: Smith J, et al.
**摘要**: 本研究利用BCOR抗体(克隆号S1122)通过免疫组化分析骨髓增生异常综合征(MDS)和急性髓系白血病(AML)中BCOR蛋白的表达缺失，发现BCOR突变与表观遗传调控异常及不良预后相关。
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2. **文献名称**: "Utility of BCOR immunohistochemistry in diagnosing undifferentiated round cell sarcomas"
**作者**: Garcia R, et al.
**摘要**: 文章验证了BCOR抗体(克隆S1122)在鉴别未分化小圆细胞肉瘤中的诊断价值，证实其在BCOR-CCNB3融合阳性肿瘤中的核染色特异性，为临床病理诊断提供了可靠工具。
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3. **文献名称**: "BCOR loss of function mutations drive epigenetic reprogramming in high-grade endometrial carcinoma"
**作者**: Li Y, et al.
**摘要**: 通过BCOR S1122抗体检测子宫内膜癌中BCOR蛋白表达，结合测序技术揭示了BCOR功能缺失突变导致组蛋白修饰异常和癌基因激活的分子机制。
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(注：上述文献为示例性内容，实际引用需根据具体研究补充完整信息。建议通过PubMed或学术数据库检索真实文献。)
The BCOR (BCL-6 Corepressor) antibody, particularly the clone S1122 (often referenced as Center S1122), targets a protein encoded by the *BCOR* gene, which functions as a transcriptional corepressor. BCOR interacts with BCL-6 and other proteins to regulate gene expression through epigenetic mechanisms, notably by forming part of the non-canonical Polycomb repressive complex 1.1 (PRC1.1). This complex mediates monoubiquitination of histone H2A, contributing to chromatin remodeling and transcriptional silencing during development and cell differentiation.
The S1122 antibody is commonly used in research to detect BCOR expression in applications like Western blotting, immunohistochemistry (IHC), or immunofluorescence (IF). It recognizes the C-terminal region of human BCOR, aiding in studies of its role in normal cellular processes and diseases. BCOR mutations or aberrant expression are linked to cancers such as clear cell sarcoma of the kidney, retinoblastoma, and hematologic malignancies like acute myeloid leukemia (AML). Additionally, germline *BCOR* alterations cause oculofaciocardiodental syndrome, highlighting its importance in developmental regulation.
Researchers utilize this antibody to explore BCOR's tumor-suppressive functions, its interaction partners, and its potential as a diagnostic or prognostic biomarker in malignancies and genetic disorders. Validation of specificity and optimal experimental conditions (e.g., tissue fixation, antibody dilution) is critical for reliable results.
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