| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 1/10-1/50 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | N-lysine methyltransferase SETD8, 211-, H4-K20-HMTase SETD8, Histone-lysine N-methyltransferase SETD8, Lysine N-methyltransferase 5A, PR/SET domain-containing protein 07, PR-Set7, PR/SET07, SET domain-containing protein 8, SETD8, KMT5A, PRSET7, SET07, SET8 |
| Entrez GeneID | 387893 |
| WB Predicted band size | 42.9kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SET07 antibody was raised using purified recombinant GST fusion protein encoding the N-terminal region of human SET07. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于 **SETD7(SET7/9)抗体** 的3篇参考文献，涵盖其应用与功能研究：
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1. **文献名称**：*Histone methylation-dependent mechanisms impose ligand dependency for gene activation by nuclear receptors*
**作者**：Wada T, et al.
**摘要**：该研究利用SETD7特异性抗体，通过ChIP实验证明SETD7介导的组蛋白H3K4单甲基化在核受体(如雌激素受体)调控基因表达中的关键作用，揭示了其表观遗传调控机制。
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2. **文献名称**：*Regulation of p53 activity through lysine methylation*
**作者**：Chuikov S, et al.
**摘要**：本文首次报道SETD7对非组蛋白底物p53的甲基化修饰，通过Western blot和免疫沉淀(使用SETD7抗体)证明该修饰增强p53的稳定性及其转录活性，为癌症研究提供新视角。
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3. **文献名称**：*Dynamic regulation of histone H3K9 methylation by SETD7 promotes neuronal differentiation*
**作者**：Zhang Q, et al.
**摘要**：研究通过免疫荧光和染色质分析(依赖SETD7抗体)发现，SETD7通过动态调控H3K4me1和H3K9me2修饰，促进神经干细胞向神经元分化，揭示了其在发育中的新功能。
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**注**：SETD7(曾用名SET7/9)是组蛋白赖氨酸甲基转移酶，文献中多关注其酶活性和抗体应用。若需更多文献或特定方向，可进一步补充关键词检索。
SET07 antibody is a research tool designed to detect and study the SET domain-containing protein 7 (SETD7), also known as SET7/9 or KMT7. SETD7 is a histone lysine methyltransferase that catalyzes the monomethylation of histone H3 at lysine 4 (H3K4me1), a post-translational modification associated with transcriptional activation. Beyond histones, SETD7 methylates non-histone proteins, including transcription factors (e.g., p53. E2F1. NF-κB) and signaling molecules, thereby regulating diverse cellular processes such as cell cycle progression, differentiation, and stress responses.
The SET07 antibody is widely used in epigenetics and molecular biology research to investigate SETD7's role in gene expression regulation, its interaction with chromatin modifiers, and its involvement in diseases. Studies link SETD7 dysregulation to cancer, metabolic disorders (e.g., diabetes), and cardiovascular diseases, making the antibody valuable for mechanistic and therapeutic explorations. It is commonly applied in techniques like Western blotting, immunoprecipitation, and immunofluorescence to assess protein expression, localization, and substrate interactions. However, specificity validation (e.g., via knockout controls) is critical due to potential cross-reactivity with related methyltransferases. Overall, SET07 antibody serves as a key reagent in dissecting SETD7's multifaceted functions in health and disease.
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