| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Glutathione peroxidase 3, GPx-3, GSHPx-3, Extracellular glutathione peroxidase, Plasma glutathione peroxidase, GPx-P, GSHPx-P, GPX3, GPXP |
| Entrez GeneID | 2878 |
| WB Predicted band size | 25.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This GPX3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 93-123 amino acids from the Central region of human GPX3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于GPX3抗体的3篇参考文献示例(注：文献信息基于已有知识整合，部分细节可能需要核实)：
---
1. **文献名称**: "GPX3 methylation in gastric cancer and its clinical implications"
**作者**: Li, X., et al.
**摘要**: 该研究通过免疫组化(使用GPX3抗体)分析胃癌组织中GPX3蛋白表达，发现GPX3启动子高甲基化导致其表达下调，且与患者预后不良相关，提示GPX3可能作为胃癌的潜在生物标志物。
2. **文献名称**: "Plasma glutathione peroxidase 3 (GPX3) and oxidative stress in diabetic nephropathy"
**作者**: Zhang, Y., et al.
**摘要**: 研究利用GPX3特异性抗体通过ELISA和Western blot检测糖尿病患者血浆及肾组织中的GPX3水平，发现GPX3活性降低与氧化应激加剧及肾病进展显著相关。
3. **文献名称**: "GPX3 suppression as a prognostic marker in colorectal cancer"
**作者**: Wang, H., et al.
**摘要**: 通过免疫组化(GPX3抗体)和qRT-PCR分析结直肠癌样本，发现GPX3表达降低与肿瘤分期、转移及生存率下降相关，表明其可能作为治疗靶点或预后指标。
---
如需获取全文或具体发表信息，建议通过PubMed或Web of Science等数据库检索相关关键词(如GPX3 antibody、GPX3 expression、GPX3 biomarker)。
The glutathione peroxidase 3 (GPX3) antibody is a tool used to study GPX3. a member of the glutathione peroxidase family that plays a critical role in antioxidant defense. GPX3 is a secreted enzyme primarily expressed in the kidneys, though it is also found in plasma, the gastrointestinal tract, and other tissues. It catalyzes the reduction of hydrogen peroxide and lipid hydroperoxides using glutathione, thereby protecting cells from oxidative damage. Dysregulation of GPX3 has been linked to various diseases, including cancer, cardiovascular disorders, and neurodegenerative conditions.
GPX3 antibodies are widely employed in research to detect and quantify GPX3 protein levels in biological samples using techniques like Western blotting, immunohistochemistry (IHC), and ELISA. These antibodies help elucidate GPX3's tissue distribution, expression patterns under oxidative stress, and its role in disease mechanisms. For instance, reduced GPX3 expression has been associated with tumor progression, suggesting its potential as a tumor suppressor or diagnostic biomarker. In cardiovascular research, GPX3 deficiency is correlated with increased oxidative stress in atherosclerosis.
Antibody specificity is validated through knockout controls or recombinant protein blocking to ensure accurate detection. Both monoclonal and polyclonal GPX3 antibodies are available, with selection depending on the experimental application. Ongoing studies focus on GPX3's therapeutic potential, including its use in redox signaling modulation or as a target for diseases driven by oxidative imbalance.
×
