Rabbit Polyclonal RPL12 Antibody

The RPL12 antibody is a crucial tool in molecular biology and biomedical research, targeting the Ribosomal Protein L12 (RPL12), a component of the 60S ribosomal subunit. RPL12 belongs to the L12 family of ribosomal proteins, which play essential roles in ribosome assembly, translation regulation, and interactions between ribosomes and translational factors. This protein is highly conserved across eukaryotes, underscoring its fundamental role in protein synthesis. Researchers use RPL12 antibodies to study its expression, localization, and interactions in various cellular contexts, including cancer, neurodegenerative diseases, and developmental biology. Dysregulation of RPL12 has been implicated in tumor progression and chemoresistance, making it a potential biomarker or therapeutic target. The antibody is commonly employed in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect RPL12 levels in tissues or cultured cells. Additionally, it aids in exploring ribosome biogenesis defects linked to genetic disorders (ribosomopathies). Validation of RPL12 antibodies typically includes testing specificity via knockout controls or siRNA knockdown. Its cross-reactivity with homologs in model organisms (e.g., mice, zebrafish) further supports translational research. Overall, RPL12 antibodies serve as vital reagents for dissecting ribosome-related mechanisms in health and disease.