Rabbit Polyclonal HAS2 Antibody

The HAS2 (hyaluronan synthase 2) antibody is a research tool designed to detect and quantify the HAS2 enzyme, which catalyzes the synthesis of hyaluronic acid (HA), a key component of the extracellular matrix. HA plays critical roles in cell migration, proliferation, and tissue hydration, with HAS2 being the primary isoform involved in HA production during embryonic development, wound healing, and pathological conditions like cancer and fibrosis. Dysregulation of HAS2 is linked to diseases such as osteoarthritis, cancer metastasis, and organ fibrosis, driving interest in its mechanistic study. The HAS2 antibody, typically developed as monoclonal or polyclonal forms, enables researchers to localize HAS2 protein expression in tissues (via immunohistochemistry) or measure its levels in cell lysates (via Western blotting or ELISA). Its applications extend to studying HA-related signaling pathways, evaluating therapeutic interventions targeting HA synthesis, and exploring HAS2's role in disease progression. Validation of antibody specificity remains crucial due to structural similarities among HAS isoforms (HAS1. HAS2. HAS3). Recent studies also highlight HAS2's involvement in inflammatory responses and stem cell differentiation, underscoring its biomedical relevance.