| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Piezo-type mechanosensitive ion channel component 2, Protein FAM38B, PIEZO2, C18orf30, C18orf58, FAM38B |
| Entrez GeneID | 63895 |
| WB Predicted band size | 31.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This FAM38B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2575-2604 amino acids of human FAM38B. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于FAM38B(PIEZO2)C端抗体的假设性参考文献示例(注：实际文献可能需要根据具体数据库检索验证)：
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1. **文献名称**：*Mechanosensitive Ion Channel PIEZO2 in Somatosensory Neurons*
**作者**：Coste B, et al.
**摘要**：本研究利用FAM38B-(C-term)抗体通过免疫印迹和免疫组化技术，验证了PIEZO2蛋白在小鼠背根神经节神经元中的特异性表达，揭示了其在机械力感知中的关键作用。
2. **文献名称**：*Antibody Validation for FAM38B C-terminal Epitope in Human Tissues*
**作者**：Smith JL, et al.
**摘要**：作者通过敲除细胞模型验证了FAM38B-(C-term)抗体的特异性，并证明其在人类皮肤组织切片中定位PIEZO2蛋白的适用性，为临床病理研究提供工具支持。
3. **文献名称**：*PIEZO2 Dysfunction in Proprioception Disorders*
**作者**：Chesler AT, et al.
**摘要**：研究使用FAM38B-C端抗体进行Western blot分析，发现遗传性 proprioception 缺陷患者中PIEZO2蛋白表达异常，提示其与神经系统疾病的关联。
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**说明**：
- FAM38B基因编码的蛋白即PIEZO2.文献中可能以PIEZO2命名为主。
- C端抗体常用于检测全长蛋白表达或特定结构域功能研究。
- 若需实际文献，建议通过PubMed检索关键词：**PIEZO2 antibody C-terminal** 或 **FAM38B antibody validation**。
The FAM38B (Family with Sequence Similarity 38. Member B) gene, also known as PIEZO1. encodes a mechanosensitive ion channel protein critical for converting mechanical stimuli into cellular signals. The FAM38B-(C-term) antibody specifically targets the C-terminal region of the PIEZO1 protein, which plays a role in channel gating, protein-protein interactions, and cellular localization. This region is essential for the protein's function in processes like vascular development, erythrocyte volume regulation, and touch sensation.
PIEZO1 is widely expressed in tissues such as the bladder, kidneys, and endothelial cells, where it mediates responses to mechanical stress. Dysregulation of PIEZO1 is linked to diseases, including hereditary xerocytosis and lymphatic dysplasia. The FAM38B-(C-term) antibody is commonly used in Western blotting, immunofluorescence, and immunohistochemistry to study PIEZO1 expression, post-translational modifications, and its role in mechanotransduction pathways. Its specificity for the C-terminal domain allows researchers to investigate structural-functional relationships and interactions with signaling partners. Validation typically includes knockout controls or peptide-blocking assays to confirm target specificity. This antibody serves as a key tool in exploring PIEZO1's contributions to physiology and disease.
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