Rabbit Polyclonal EphA7 Antibody

The EphA7 antibody is a crucial tool for studying the EphA7 receptor, a member of the Ephrin (Eph) receptor tyrosine kinase family. Eph receptors and their membrane-bound ephrin ligands play pivotal roles in cell-cell communication, regulating processes such as embryonic development, tissue patterning, and cell migration. EphA7. specifically, is involved in axon guidance, synaptic plasticity, and boundary formation during neurodevelopment. Dysregulation of EphA7 has been implicated in cancer, where it may act as either a tumor suppressor or promoter depending on context. For instance, EphA7 downregulation is linked to glioblastoma progression, while its overexpression correlates with poor prognosis in lung and colorectal cancers. The EphA7 antibody enables detection and localization of EphA7 protein in tissues or cells via techniques like Western blotting, immunohistochemistry, or flow cytometry. Researchers use it to explore EphA7's expression patterns, signaling mechanisms, and interactions with ephrin ligands. Its role in bidirectional signaling (forward and reverse) makes it essential for understanding cellular responses in both physiological and pathological states. Recent studies highlight EphA7's potential as a therapeutic target, particularly in cancers and neurological disorders. However, conflicting findings across studies underscore the need for reliable, validated EphA7 antibodies to ensure reproducibility in research.