| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Protein FAM43A, FAM43A |
| Entrez GeneID | 131583 |
| WB Predicted band size | 45.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This FAM43A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 80-108 amino acids from the N-terminal region of human FAM43A. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于FAM43A(N-term)抗体的假设性参考文献示例(需核实具体文献是否存在)：
1. **文献名称**: *FAM43A suppresses colorectal cancer progression by inhibiting Wnt/β-catenin signaling*
**作者**: Zhang L, et al.
**摘要**: 研究通过FAM43A(N-term)抗体进行Western blot和免疫组化，发现FAM43A在结直肠癌中低表达，并通过抑制Wnt通路发挥肿瘤抑制作用。
2. **文献名称**: *FAM43A interacts with EGFR to modulate cell proliferation in breast cancer*
**作者**: Wang Y, et al.
**摘要**: 利用FAM43A(N-term)抗体进行免疫共沉淀实验，证实FAM43A与EGFR直接结合，抑制乳腺癌细胞增殖和体内成瘤能力。
3. **文献名称**: *FAM43A as a potential biomarker for hepatocellular carcinoma prognosis*
**作者**: Chen H, et al.
**摘要**: 通过FAM43A(N-term)抗体的免疫荧光分析，发现FAM43A在肝癌组织中的表达与患者生存率显著相关，可能成为预后标志物。
4. **文献名称**: *FAM43A regulates cell cycle progression via p53 signaling*
**作者**: Kim S, et al.
**摘要**: 使用FAM43A(N-term)抗体进行蛋白质定位研究，揭示FAM43A通过稳定p53蛋白调控细胞周期G1/S期转换。
**注意**：以上文献及内容为示例性质，实际研究中需通过PubMed或Google Scholar等平台检索真实文献。若需具体文献，建议补充实验背景或提供DOI编号进一步筛选。
The FAM43A (N-term) antibody is a polyclonal or monoclonal antibody specifically designed to target the N-terminal region of the FAM43A (Family with Sequence Similarity 43 Member A) protein. FAM43A is a relatively understudied protein encoded by the FAM43A gene, which is conserved across vertebrates and implicated in various cellular processes, including cell signaling, proliferation, and potential roles in cancer biology. The N-terminal region of FAM43A may contain functional domains critical for its interactions with other proteins or regulatory mechanisms, though its exact molecular functions remain to be fully elucidated.
This antibody is commonly used in research applications such as Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF) to detect FAM43A expression levels, subcellular localization, and tissue distribution. It is typically raised in hosts like rabbits or mice using synthetic peptides or recombinant protein fragments corresponding to the N-terminal sequence of human FAM43A. Validation often includes testing in cell lines with confirmed FAM43A expression or knockout controls to ensure specificity. The antibody helps investigate FAM43A's role in disease contexts, such as cancer, where altered expression has been observed. Researchers rely on its specificity to explore FAM43A's interactions, post-translational modifications, and potential as a biomarker or therapeutic target.
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