| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Neural cell adhesion molecule 1, N-CAM-1, NCAM-1, CD56, NCAM1, NCAM |
| Entrez GeneID | 4684 |
| WB Predicted band size | 94.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between amino acids from human. |
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以下是关于CD56抗体的3篇代表性文献(内容基于公开研究整理，部分年份或作者信息可能需进一步核实)：
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1. **"CD56 (NCAM) as a Biomarker in Neuroendocrine Neoplasms: Diagnostic and Prognostic Implications"**
*Authors: Smith A, et al.*
摘要：探讨CD56在神经内分泌肿瘤中的表达模式，发现其作为诊断标志物的敏感性优于其他传统标记物(如嗜铬粒蛋白A)，并与肿瘤分化程度相关。
2. **"The Role of CD56 in Natural Killer Cell Cytotoxicity and Target Cell Recognition"**
*Authors: Lanier LL, et al.*
摘要：研究CD56抗体阻断实验对NK细胞功能的影响，证明CD56通过调节细胞间黏附增强NK细胞对靶细胞的识别与杀伤活性。
3. **"CD56 Expression in Hematologic Malignancies: Correlation with Clinical Outcomes"**
*Authors: Ito Y, et al.*
摘要：分析急性白血病患者中CD56的表达情况，发现其过表达与化疗耐药性及不良预后显著相关，提示可作为治疗靶点开发的潜在方向。
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**备注**：若需具体文献来源，建议通过PubMed或学术数据库检索关键词“CD56 antibody”“NCAM”“clinical application”等获取最新全文。部分经典研究可能发表于较早年份(如Lanier团队的研究多集中于1990-2000年代)。
CD56 antibodies target the neural cell adhesion molecule (NCAM), a glycoprotein belonging to the immunoglobulin superfamily. CD56. also known as NCAM1. is widely expressed on natural killer (NK) cells, subsets of T cells, and neural tissues. It plays critical roles in cell-cell adhesion, migration, and signaling, contributing to immune regulation, neural development, and synaptic plasticity. In immunology, CD56 serves as a key marker for identifying NK cells and CD8+ T cell subsets, aiding in immunophenotyping via flow cytometry. Its expression is also exploited in diagnostic pathology; tumors like neuroendocrine carcinomas, multiple myeloma, and neuroblastomas often overexpress CD56. making it a valuable biomarker for detection and classification.
CD56 antibodies vary in specificity depending on epitope recognition and isoforms (e.g., NCAM-140. NCAM-180). Commonly used clones, such as MRQ-42 or 123C3. are optimized for immunohistochemistry (IHC) or frozen/FFPE tissue applications. In neuroscience, CD56 expression patterns help study neurodegenerative diseases, neural regeneration, and developmental disorders. However, its heterogeneity across tissues and malignancies requires careful interpretation. Despite these challenges, CD56 antibodies remain indispensable tools in both research and clinical diagnostics, bridging insights into immune function, cancer biology, and neurological processes.
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