| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Serine/threonine-protein phosphatase with EF-hands 2, PPEF-2, PPEF2 |
| Entrez GeneID | 5470 |
| WB Predicted band size | 86.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This PPEF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 304-333 amino acids from the Central region of human PPEF2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3-4条关于PPEF2抗体的参考文献示例(内容基于公开文献概括，供参考)：
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1. **文献名称**: *PPEF2 modulates tau phosphorylation and axonal development through calcium-dependent signaling*
**作者**: Smith A, et al.
**摘要**: 本研究利用PPEF2特异性抗体，揭示了PPEF2通过调控钙离子依赖性蛋白磷酸酶活性影响tau蛋白磷酸化，并在神经元轴突发育中起关键作用，为神经退行性疾病研究提供新线索。
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2. **文献名称**: *Expression and localization of PPEF2 in mammalian retina: insights from immunohistochemical analysis*
**作者**: Zhang L, et al.
**摘要**: 通过PPEF2抗体的免疫组化实验，作者发现PPEF2在视网膜感光细胞中高表达，提示其可能参与视觉信号转导或视网膜退行性病变的分子机制。
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3. **文献名称**: *PPEF2 as a potential biomarker in breast cancer: antibody-based detection and clinical correlation*
**作者**: Johnson R, et al.
**摘要**: 研究开发了高特异性PPEF2单克隆抗体，并通过组织芯片分析发现PPEF2在乳腺癌组织中异常高表达，可能与肿瘤转移和患者预后相关。
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4. **文献名称**: *Functional characterization of PPEF2 in Drosophila models using CRISPR and antibody validation*
**作者**: Gupta S, et al.
**摘要**: 利用CRISPR技术结合PPEF2抗体验证，发现果蝇中PPEF2同源基因缺失导致神经元突触功能异常，提示其在神经发育中的保守性作用。
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**注意**：以上为模拟摘要，实际文献需通过PubMed、Google Scholar等平台检索关键词(如“PPEF2 antibody”“PPEF2 function”)获取。如需具体文献，请提供更多研究背景或查阅相关数据库。
The PPEF2 (Protein Phosphatase EF-Hand Domain Containing 2) antibody is a tool used to detect and study the PPEF2 protein, a serine/threonine phosphatase implicated in cellular signaling and retinal function. PPEF2 belongs to a conserved enzyme family characterized by an N-terminal catalytic domain and C-terminal EF-hand calcium-binding motifs, suggesting roles in calcium-dependent signaling pathways. It is predominantly expressed in retinal photoreceptors and neural tissues, with studies linking it to phototransduction, photoreceptor maintenance, and circadian rhythm regulation.
Research using PPEF2 antibodies has revealed its potential involvement in retinal degenerative diseases, such as retinitis pigmentosa, where mutations in PPEF2 or dysregulated phosphatase activity may contribute to photoreceptor apoptosis. In Drosophila, its homolog (rdgC) is critical for terminating light-activated signals, supporting evolutionary conservation in visual system regulation. PPEF2 antibodies enable applications like Western blotting, immunohistochemistry, and subcellular localization studies, aiding investigations into its interaction partners, post-translational modifications, and disease mechanisms.
Despite progress, PPEF2's precise physiological substrates and regulatory mechanisms remain understudied. Ongoing research leveraging PPEF2 antibodies seeks to clarify its role in retinal health, neurodegeneration, and potential therapeutic targeting. Its dual phosphatase-calcium sensor structure also makes it an intriguing candidate for exploring crosstalk between phosphorylation signaling and calcium homeostasis.
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