Rabbit Polyclonal p73(Phospho-Tyr99) Antibody

The p73 (Phospho-Tyr99) antibody is a specialized tool used to detect the phosphorylated form of the p73 protein at tyrosine residue 99. p73. a member of the p53 tumor suppressor family, plays critical roles in regulating cell cycle arrest, apoptosis, and differentiation. Unlike p53. p73 exists as multiple isoforms due to alternative splicing, with both transactivation-competent (TAp73) and transactivation-deficient (ΔNp73) variants exhibiting opposing functions in cellular processes. Phosphorylation at Tyr99 is a post-translational modification implicated in modulating p73 activity, stability, or interactions with other signaling molecules, though its precise mechanistic role remains under investigation. This antibody is particularly valuable in studies exploring DNA damage response pathways, oncogenic signaling, or p73-dependent regulatory networks. It enables researchers to assess the activation status or functional modulation of p73 in contexts such as cancer, neurodegeneration, or developmental disorders. Validated applications typically include Western blotting, immunoprecipitation, and immunofluorescence, often paired with controls (e.g., phosphatase treatment or non-phosphorylated mutants) to confirm specificity. Its utility extends to both basic research—elucidating p73 signaling dynamics—and translational studies targeting p73 dysregulation in diseases.