Rabbit Polyclonal Tau(Phospho-Ser214) Antibody

中文名： Tau(Phospho-Ser214)抗体
别名： MAPT; MTAPT; MTBT1; Neurofibrillary tangle protein; PHF-tau

货号: IPDX40107

Price： ￥1280

50μl 100μl

数量：

大包装询价

验证与应用

应用及物种

WB	咨询技术	Human,Mouse,Rat
IF	咨询技术	Human,Mouse,Rat
IHC	咨询技术	Human,Mouse,Rat
ICC	技术咨询	Human,Mouse,Rat
FCM	咨询技术	Human,Mouse,Rat
Elisa	咨询技术	Human,Mouse,Rat

产品详情

Aliases	MAPT; MTAPT; MTBT1; Neurofibrillary tangle protein; PHF-tau
Entrez GeneID	4137;
WB Predicted band size	48 62 78 kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Peptide sequence around phosphorylation site of serine 214 (T-P-S(p)-L-P) derived from Human Tau.
Formulation	Purified antibody in PBS with 0.05% sodium azide.

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Western blot analysis of extracts from mouse brain tissue using Tau(Phospho-Ser214) Antibody P40107 and the same antibody preincubated with blocking peptide.

参考文献

以下是关于Tau (Phospho-Ser214)抗体的3篇参考文献及其简要摘要：

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1. **文献名称**：*Phosphorylation of Serine 214 in Tau Protein: Implications for Alzheimer’s Disease*

**作者**：Hasegawa, M. et al.

**摘要**：该研究分析了Tau蛋白在Ser214位点的磷酸化对阿尔茨海默病中神经纤维缠结形成的影响，发现该位点的磷酸化可能通过调控Tau与微管的结合能力促进病理聚集。

2. **文献名称**：*Site-Specific Phosphorylation of Tau Inhibits Amyloid-β Toxicity in Alzheimer’s Mice*

**作者**：Biernat, J. et al.

**摘要**：通过转基因小鼠模型，揭示了Tau蛋白Ser214磷酸化在Aβ毒性中的保护作用，并利用特异性抗体证明该修饰可能通过改变Tau构象减轻神经元损伤。

3. **文献名称**：*Role of Phospho-Ser214-Tau in Neurodegenerative Tauopathies*

**作者**：Schneider, A. et al.

**摘要**：利用Tau (Phospho-Ser214)抗体在多系统萎缩和额颞叶痴呆组织样本中检测到该位点的异常磷酸化，提示其与Tau蛋白错误定位及疾病进展相关。

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注：上述文献名为示例性概括，实际文献需通过PubMed/Google Scholar等平台以关键词“Tau Phospho-Ser214 antibody”检索确认。

背景信息

The Tau (Phospho-Ser214) antibody is a specialized tool used to detect tau protein phosphorylated at serine residue 214. a post-translational modification implicated in neurodegenerative diseases. Tau, a microtubule-associated protein, stabilizes neuronal microtubules and supports axonal transport. Its function is regulated by phosphorylation, which modulates microtubule binding affinity. Hyperphosphorylation of tau disrupts this interaction, leading to microtubule destabilization and pathological aggregation into neurofibrillary tangles (NFTs), a hallmark of Alzheimer’s disease (AD) and other tauopathies.

Phosphorylation at Ser214 is of particular interest due to its proximity to the microtubule-binding domain. Studies suggest that phosphorylation at this site reduces tau’s affinity for microtubules and may promote pathological aggregation. The Tau (Phospho-Ser214) antibody enables researchers to investigate spatial-temporal phosphorylation patterns in disease models, clinical samples, or experimental systems. It is commonly employed in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess tau phosphorylation dynamics in response to cellular stressors, kinase/phosphatase activity, or therapeutic interventions.

This antibody contributes to understanding tau pathology mechanisms, validating disease biomarkers, and evaluating potential therapies targeting tau hyperphosphorylation. Its specificity for the Ser214 site helps distinguish phosphorylation-dependent tau dysfunction from other regulatory modifications, offering insights into AD progression and related disorders.