| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | tyrosine kinase 2; JTK1; |
| Entrez GeneID | 7297; |
| WB Predicted band size | 140kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Peptide sequence around phosphorylation site of tyrosine 1054 (H-E-Y(p)-Y-R) derived from Human TYK2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于 TYK2 (Phospho-Tyr1054) 抗体的虚构参考文献示例(注：以下内容为模拟生成，实际文献需通过数据库检索确认)：
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1. **文献名称**: *Structural basis of TYK2 activation by phosphorylation at Tyr1054*
**作者**: Müller, C. et al.
**摘要**: 本研究通过X射线晶体学分析了TYK2激酶结构域在Tyr1054磷酸化后的构象变化，揭示了该位点磷酸化如何促进TYK2的活性构象及与下游信号蛋白的相互作用。
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2. **文献名称**: *TYK2 phosphorylation at Tyr1054 regulates interferon signaling in autoimmune diseases*
**作者**: Pellegrini, S. & Nguyen, K.B.
**摘要**: 文章利用特异性抗TYK2 (Phospho-Tyr1054) 抗体，证明该位点的磷酸化水平在系统性红斑狼疮患者外周血细胞中显著升高，提示其作为疾病生物标志物的潜力。
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3. **文献名称**: *Development of a phospho-specific antibody for TYK2 Tyr1054 and its application in cancer immunotherapy*
**作者**: Wang, L. et al.
**摘要**: 研究报道了一种高特异性抗TYK2 (Phospho-Tyr1054) 抗体的开发，并通过免疫组化证实其在黑色素瘤组织中异常激活的TYK2信号通路，为靶向治疗提供依据。
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4. **文献名称**: *TYK2 Tyr1054 phosphorylation mediates IL-12/IL-23 signaling in dendritic cells*
**作者**: Ghoreschi, K. et al.
**摘要**: 利用Phospho-Tyr1054抗体阻断实验，揭示了TYK2该位点的磷酸化在树突状细胞IL-12/IL-23分泌中的关键作用，为炎症性疾病机制研究提供新方向。
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**提示**：建议通过PubMed或Google Scholar检索关键词“TYK2 Phospho-Tyr1054 antibody”获取真实文献，并结合实验目的筛选(如WB、IP、IHC等应用场景)。
The TYK2 (Phospho-Tyr1054) antibody is a specialized tool used to detect the phosphorylated form of Tyrosine Kinase 2 (TYK2) at tyrosine residue 1054. TYK2. a member of the Janus kinase (JAK) family, plays a critical role in cytokine signaling through the JAK-STAT pathway. Phosphorylation at Tyr1054. located in the kinase domain, is essential for TYK2 activation, enabling its interaction with cytokine receptors and downstream signaling mediators like STAT proteins. This post-translational modification regulates immune responses, cell growth, and inflammatory processes.
The antibody is commonly employed in research to study TYK2 activation dynamics in immune disorders, cancer, and autoimmune diseases. It is validated for applications such as Western blotting, immunoprecipitation, and immunohistochemistry, helping researchers assess TYK2 activity in cellular or tissue samples. Specificity is ensured through controls comparing phosphorylated and non-phosphorylated TYK2 states.
Dysregulated TYK2 signaling is linked to conditions like psoriasis, lupus, and certain cancers, making this antibody valuable for mechanistic studies and therapeutic target validation. Its use contributes to understanding how TYK2 phosphorylation modulates disease pathways or drug responses, particularly in the context of JAK-STAT inhibitors. Proper validation and optimization are recommended to account for cell type-specific phosphorylation levels and experimental conditions.
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