Rabbit Polyclonal a-Synuclein(Phospho-Tyr136) Antibody

The a-synuclein (Phospho-Tyr136) antibody is a specialized tool used to detect the phosphorylated form of alpha-synuclein at tyrosine residue 136 (Y136). Alpha-synuclein is a presynaptic protein implicated in neurodegenerative disorders, particularly Parkinson’s disease (PD) and other synucleinopathies. In its native state, it regulates synaptic vesicle trafficking and neurotransmitter release. However, abnormal aggregation of alpha-synuclein into insoluble fibrils is a hallmark of these diseases, forming Lewy bodies and Lewy neurites. Post-translational modifications, including phosphorylation, are believed to modulate its aggregation, toxicity, and disease progression. Phosphorylation at Y136 has been identified as a pathological modification that enhances alpha-synuclein’s propensity to aggregate and may contribute to neurotoxicity. This phosphorylation event is thought to influence protein-protein interactions, subcellular localization, and clearance mechanisms. The a-synuclein (Phospho-Tyr136) antibody is essential for studying the role of this modification in disease models, enabling researchers to detect phosphorylated alpha-synuclein in cellular assays, animal tissues, or human postmortem samples. It is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to explore phosphorylation dynamics in pathological contexts. Understanding Y136 phosphorylation could aid in developing targeted therapies to inhibit abnormal alpha-synuclein modifications or promote its clearance, offering potential avenues for treating synucleinopathies.