Cat: PA2000-170DB

Recombinant Human C4BPa Protein,His

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关键信息

  • 基因名

    C4BPa

  • 应用

    SPRMSTBLIITCELISA细胞实验药物筛选

  • 别名

    C4BPa;C4BP;C4b-binding Protein alpha chain

  • 种属

    Human

  • 表达系统

    E. coli

  • 标签

    His tag N-Terminus

  • 纯度

    Greater than 90% as determined by SDS-PAGE.

  • 蛋白编号

    P04003

  • 表达区间

    49-597aa

  • 氨基酸序列

    NCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNTFCIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEKITCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWTPYQGCEALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSCHETSRFSAICQGDGTWSPRTPSCGDICNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYSHWSAPAPQCKALCRKPELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKCEWETPEGCEQVLTGKRLMQCLPNPEDVKMALEVYKLSLEIEQLELQRDSARQSTLDKEL

  • 分子量

    63.7kDa

  • 内毒素

    < 1.0 EU per μg protein as determined by the LAL method.

  • 性状

    Freeze-dried powder

  • 缓冲液

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • 复溶方法

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • 个性化定制

    点位突变 标签定制 buffer定制 全长蛋白定制

  • 稳定性测试

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • 保存条件 & 期限

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • 运输条件

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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背景信息

C4BPa, or complement component 4 binding protein alpha, is a crucial regulatory protein involved in the complement system, an integral part of the immune response. It exists as a hetero-oligomeric complex that plays a significant role in modulating inflammation and immune responses by binding to and inactivating complement proteins, particularly C4b and C3b. The dysregulation of C4BPa has been associated with various pathological conditions, including autoimmune diseases, infections, and cardiovascular diseases, highlighting its potential as a therapeutic target. Recent studies have focused on the recombinant expression of C4BPa to better understand its structural and functional properties. Researchers aim to characterize the protein’s binding interactions and regulatory mechanisms, providing insights into its role in immune regulation. Understanding C4BPa's structure-function relationship could pave the way for novel therapeutic interventions, including the development of drugs that mimic or inhibit its activity to enhance immune responses in disease contexts. Additionally, the recombinant version of C4BPa offers a tool for further investigation into the complement system's dynamics, with the potential for application in diagnostic and therapeutic settings. Researchers are also exploring the implications of C4BPa in various diseases, making it a focal point for studies aimed at unraveling the complexities of immune regulation and the development of targeted therapies. Overall, ongoing research into C4BPa not only contributes to our understanding of complement regulation but also holds promise for advancing immune-related therapies and improving patient outcomes in a range of diseases.

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