| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | BING2; DAP6 |
| Entrez GeneID | 1616; |
| WB Predicted band size | 81kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Peptide sequence around phosphorylation site of serine 739 (L-S-D-S(p)-D) derived from Human DAXX. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于 DAXX(Phospho-Ser739) 抗体的3篇参考文献示例(注：文献为虚拟示例，实际检索时需验证数据库)：
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1. **文献名称**: *"Phosphorylation of DAXX at Ser739 regulates its apoptotic function in oxidative stress response"*
**作者**: Miyazaki T. et al.
**摘要**: 研究报道了DAXX在氧化应激条件下通过ATM激酶介导的Ser739位点磷酸化，促进其从细胞核向胞质转位，并增强与ASK1的相互作用，从而调控细胞凋亡。文中使用Phospho-Ser739特异性抗体通过免疫印迹验证了磷酸化水平变化。
2. **文献名称**: *"DAXX Ser739 phosphorylation modulates its interaction with histone H3.3 in cancer progression"*
**作者**: Johnson R.B. et al.
**摘要**: 该研究通过免疫沉淀结合质谱分析，发现DAXX的Ser739磷酸化可增强其与组蛋白伴侣复合物的结合，促进H3.3在端粒区的沉积。研究利用Phospho-Ser739抗体进行ChIP-seq实验，揭示了该位点磷酸化与肿瘤侵袭性的关联。
3. **文献名称**: *"A novel antibody-based assay for detecting DAXX phosphorylation in clinical samples"*
**作者**: Chen L. et al.
**摘要**: 开发了一种针对DAXX Ser739磷酸化位点的ELISA检测方法，验证了抗体在多种癌症组织中的特异性，并发现磷酸化水平与患者预后显著相关。研究强调了该抗体在临床诊断中的潜在应用价值。
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**提示**：实际研究中建议通过 **PubMed** 或 **Google Scholar** 检索关键词“DAXX Ser739 phosphorylation antibody”获取最新文献，部分抗体厂商(如CST、Abcam)的产品说明书也会引用相关研究。
The DAXX (Phospho-Ser739) antibody is a specialized tool used to detect the phosphorylation status of the DAXX protein at serine residue 739. a post-translational modification critical for its functional regulation. DAXX (Death Domain-Associated Protein 6) is a multifunctional nuclear protein involved in transcriptional regulation, chromatin remodeling, apoptosis, and DNA damage response. Phosphorylation at Ser739 is linked to cellular stress signaling, particularly in response to DNA damage. Studies suggest this modification may be mediated by kinases such as ATM/ATR, which are activated during genotoxic stress, and could modulate DAXX's interactions with partners like MDM2. thereby influencing p53-dependent pathways and cell fate decisions.
The antibody is widely employed in research to investigate DAXX's role in tumor suppression, apoptosis, and genomic stability. Its specificity for the phosphorylated form enables researchers to analyze dynamic changes in DAXX activity under conditions like oxidative stress, chemotherapy, or radiation. Validated applications include Western blotting, immunofluorescence, and immunoprecipitation, often using cell lysates treated with DNA-damaging agents as positive controls. Dysregulation of DAXX phosphorylation has been implicated in cancer progression and neurodegenerative diseases, making this antibody a valuable tool for mechanistic studies and potential therapeutic targeting. Proper controls, such as phosphatase-treated samples, are essential to confirm signal specificity.
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