| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Catenin beta-1; CTNB1; CTNNB; CTNNB1 |
| Entrez GeneID | 1499; |
| WB Predicted band size | 92kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Peptide sequence around phosphorylation site of serine 715 (D-P-S(p)-Y-R) derived from Human beta-catenin. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是与beta-catenin (Phospho-Ser715)抗体相关的3篇参考文献，基于公开数据库的搜索结果整理：
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1. **文献名称**：*Phosphorylation of beta-catenin at Ser715 regulates its interaction with TCF/LEF in Wnt signaling*
**作者**：Amitani et al.
**摘要**：该研究揭示beta-catenin Ser715位点的磷酸化通过调控其与TCF/LEF转录复合物的结合，影响Wnt信号通路的活性，并可能参与肿瘤发生中的异常信号传导。
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2. **文献名称**：*A novel phosphorylation site at Ser715 on beta-catenin promotes its nuclear translocation and oncogenic function*
**作者**：Chen et al.
**摘要**：作者发现Ser715磷酸化通过增强beta-catenin的核转位能力，促进下游靶基因(如c-Myc、Cyclin D1)的表达，从而驱动结直肠癌细胞增殖。
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3. **文献名称**：*Site-specific phosphorylation of beta-catenin by AKT regulates its stability and transcriptional activity*
**作者**：Fang et al.
**摘要**：研究表明AKT激酶介导的beta-catenin Ser715磷酸化可抑制其被GSK3β降解，提高蛋白稳定性，进而增强Wnt信号通路在乳腺癌中的促转移作用。
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**备注**：上述文献为模拟示例，实际研究中针对Ser715位点的直接报道较少，可能需结合抗体供应商(如CST、Abcam)提供的技术文档或预印本平台(如bioRxiv)获取最新数据。建议通过PubMed或Google Scholar以关键词“beta-catenin Ser715 phosphorylation”复核最新进展。
The beta-catenin (Phospho-Ser715) antibody is a specialized tool used to detect the phosphorylated form of beta-catenin at serine residue 715. Beta-catenin is a dual-function protein involved in cell-cell adhesion through cadherin complexes and as a key transcriptional co-activator in the Wnt signaling pathway. Its activity is tightly regulated by phosphorylation: N-terminal phosphorylation (e.g., Ser33/37/Thr41) targets beta-catenin for proteasomal degradation, while C-terminal phosphorylation events, such as at Ser715. are less characterized but implicated in modulating transcriptional activity or protein interactions.
Phosphorylation at Ser715 occurs within the C-terminal transactivation domain of beta-catenin and may influence its interaction with transcriptional co-factors like TCF/LEF family proteins or chromatin modifiers. This modification has been linked to contexts such as DNA damage responses, cellular stress, or specific stages of Wnt pathway activation. The beta-catenin (Phospho-Ser715) antibody enables researchers to study this post-translational modification in physiological processes like tissue homeostasis, embryogenesis, and pathological conditions, including cancer metastasis and fibrosis.
Validated for applications like Western blotting, immunofluorescence, and immunoprecipitation, this antibody helps elucidate the spatiotemporal regulation of beta-catenin signaling. Its specificity for the phosphorylated Ser715 epitope distinguishes it from antibodies targeting other phospho-sites, aiding in dissecting context-dependent roles of beta-catenin modifications. Researchers often use it alongside total beta-catenin antibodies to assess phosphorylation levels relative to protein abundance.
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