Rabbit Polyclonal hnRPD(Phospho-Ser83) Antibody

The hnRNP D (Phospho-Ser83) antibody is designed to detect the phosphorylation of serine residue 83 in heterogeneous nuclear ribonucleoprotein D (hnRNP D), also known as AU-rich element RNA-binding protein 1 (AUF1). hnRNP D is a multifunctional RNA-binding protein involved in mRNA stability, splicing, and translation regulation. Its activity is tightly regulated by post-translational modifications, including phosphorylation. Phosphorylation at Ser83. mediated by stress-activated kinases such as MK2/MK3. modulates hnRNP D’s RNA-binding affinity and subcellular localization, particularly under cellular stress conditions like heat shock, UV radiation, or DNA damage. This modification can influence its ability to bind AU-rich elements (AREs) in the 3' untranslated regions (UTRs) of target mRNAs, thereby altering the stability or decay of transcripts encoding cytokines, proto-oncogenes, and cell cycle regulators. The hnRNP D (Phospho-Ser83) antibody is widely used in research to study stress response pathways, inflammation, and cancer biology. It helps identify phosphorylated hnRNP D in techniques like Western blotting, immunoprecipitation, and immunofluorescence, providing insights into its role in diseases associated with dysregulated mRNA metabolism. Understanding Ser83 phosphorylation dynamics is critical for unraveling hnRNP D’s regulatory mechanisms in cellular adaptation and pathological states.