| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CMD1, CMPD1, SRA1 |
| Entrez GeneID | 6662; |
| WB Predicted band size | 69kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Peptide sequence around phosphorylation site of Serine 181 (R-K-S(p)-V-K) derived from Human SOX-9. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下为模拟生成的关于SOX-9 (Phospho-Ser181)抗体的参考文献示例(非真实文献，仅供格式参考)：
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1. **文献名称**：Phosphorylation of SOX-9 at Ser181 Modulates Chondrocyte Differentiation
**作者**：Lee, H. et al.
**摘要**：研究揭示了SOX-9在Ser181位点的磷酸化通过激活Wnt/β-catenin通路促进软骨细胞分化，使用Phospho-Ser181特异性抗体验证了该修饰在体外模型中的动态变化。
2. **文献名称**：SOX-9 Phosphorylation Status in Prostate Cancer Metastasis
**作者**：Smith, J.R. & Zhang, Q.
**摘要**：通过免疫组化结合Phospho-Ser181抗体，发现SOX-9的磷酸化水平与前列腺癌侵袭性呈正相关，提示其可作为预后标志物。
3. **文献名称**：Kinase-Dependent Regulation of SOX-9 via Ser181 Phosphorylation
**作者**：Garcia, M. et al.
**摘要**：利用Phospho-Ser181抗体筛选发现，PKA激酶介导的SOX-9磷酸化增强其转录活性，调控靶基因Col2a1在软骨发育中的表达。
4. **文献名称**：A Novel Role of SOX-9 Phosphorylation in Hepatic Fibrosis
**作者**：Wang, Y. et al.
**摘要**：研究通过Western blot和免疫荧光(使用Phospho-Ser181抗体)证实，肝星状细胞中SOX-9的磷酸化驱动纤维化相关基因表达，为治疗提供新靶点。
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**提示**：以上为模拟示例。实际文献建议通过PubMed或Google Scholar以关键词“SOX-9 Phospho-Ser181 antibody”检索，并筛选涉及抗体应用、机制或疾病关联的研究。
The SOX-9 (Phospho-Ser181) antibody is a specialized tool used to detect the phosphorylated form of SOX-9 at serine residue 181. a post-translational modification critical for regulating its biological activity. SOX-9. a member of the SOX (SRY-related HMG-box) transcription factor family, plays essential roles in embryonic development, chondrogenesis, and sex determination. It is also implicated in maintaining stem cell properties and tissue homeostasis. Phosphorylation at Ser181. located within the transactivation domain of SOX-9. enhances its transcriptional activity by promoting nuclear retention, DNA binding, and interaction with co-regulators. This modification is dynamically regulated by signaling pathways such as PKA and MAPK, linking extracellular cues to SOX-9-dependent gene expression.
The SOX-9 (Phospho-Ser181) antibody is widely utilized in research to study cellular differentiation, skeletal development, and diseases involving SOX-9 dysregulation, including cancers, cartilage disorders, and campomelic dysplasia. Specificity validation via knockout controls or phosphatase treatment ensures accurate detection of the phosphorylated epitope. Applications include Western blotting, immunohistochemistry, and immunofluorescence to assess phosphorylation status in cell lines, tissues, or disease models. Understanding SOX-9 phosphorylation provides insights into mechanisms underlying developmental defects and pathological conditions, making this antibody a key reagent in molecular and translational studies.
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