| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | EEC3; KET; LMS; p51; p73H; p73L; SHFM4; TA p63 alpha; TP63; tumor protein p63 |
| Entrez GeneID | 8626; |
| WB Predicted band size | 77kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Peptide sequence around phosphorylation site of serine 395 (R-R-S(p)-P-D) derived from Human p63. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于p63 (Phospho-Ser395)抗体的参考文献示例(内容为模拟，仅供参考)：
1. **"ATM-mediated phosphorylation of p63 at Serine 395 promotes apoptosis in response to DNA damage"**
- **作者**: Dellambra E. et al.
- **摘要**: 研究揭示了ATM激酶在DNA损伤后磷酸化p63的Ser395位点，促进其促凋亡功能，并阐明了该修饰在维持基因组稳定性中的作用。
2. **"Phosphorylation of p63 on Serine 395 modulates transcriptional regulation of epidermal differentiation genes"**
- **作者**: Koster M.I. et al.
- **摘要**: 通过Phospho-Ser395抗体检测，发现该磷酸化修饰抑制p63的转录活性，影响表皮干细胞分化和屏障功能。
3. **"p63 phosphorylation at Ser395 by CK1δ drives oncogenic signaling in squamous cell carcinoma"**
- **作者**: Truong A.B. et al.
- **摘要**: 在鳞状细胞癌中，CK1δ介导的Ser395磷酸化增强p63的促增殖功能，Phospho-Ser395抗体用于验证该修饰与患者预后不良的相关性。
4. **"A novel role for p63 phosphorylation in neural crest development"**
- **作者**: Rouleau M. et al.
- **摘要**: 利用Phospho-Ser395特异性抗体，揭示该位点的磷酸化调控p63在胚胎神经嵴细胞迁移中的动态表达模式。
**注**：以上文献为示例，实际引用需以真实发表的论文为准，建议通过PubMed或Google Scholar检索关键词“p63 Ser395 phosphorylation”获取最新研究。
The p63 protein, encoded by the TP63 gene, is a member of the p53 tumor suppressor family and plays critical roles in epithelial development, stem cell maintenance, and tissue homeostasis. It exists as multiple isoforms, primarily TAp63 (transactivation-competent) and ΔNp63 (N-terminal truncated), which regulate distinct cellular processes such as apoptosis, differentiation, and proliferation. Phosphorylation at specific residues modulates p63 activity, stability, and interactions with other proteins. The p63 (Phospho-Ser395) antibody specifically detects p63 when phosphorylated at serine 395. a post-translational modification implicated in regulating protein function under stress or DNA damage conditions.
This phosphorylation event is associated with modulating p63's transcriptional activity, protein-protein interactions, and subcellular localization. Studies suggest that Ser395 phosphorylation may influence p63's role in cellular senescence, cancer progression, or response to therapeutic agents. The antibody is widely used in research to investigate p63 signaling dynamics in contexts like squamous cell carcinomas, developmental biology, and epithelial integrity. It is validated in applications including Western blotting, immunohistochemistry, and immunofluorescence, often in human or murine samples. Understanding p63 phosphorylation at Ser395 provides insights into its dual tumor-suppressive or oncogenic roles, depending on isoform expression and cellular context.
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