| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/40000 | Human,Mouse,Rat |
| Aliases | MST1R; PTK8; RON; Macrophage-stimulating protein receptor; MSP receptor; CDw136; Protein-tyrosine kinase 8; p185-Ron; CD antigen CD136 |
| Entrez GeneID | 4486; |
| WB Predicted band size | 152kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from human Ron around the phosphorylation site of S1394. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于Ron (Phospho-Ser1394)抗体的示例参考文献(注：以下文献为示例，实际文献需通过学术数据库查询)：
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1. **文献名称**：*Phosphorylation of Ron receptor tyrosine kinase at Serine 1394 regulates cell migration in response to hepatocyte growth factor-like protein*
**作者**：Smith A, et al.
**摘要**：研究揭示了Ron受体在Ser1394位点的磷酸化通过调控下游MAPK信号通路促进肿瘤细胞迁移，并通过Phospho-Ser1394特异性抗体验证了其在乳腺癌模型中的作用。
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2. **文献名称**：*Structural basis of Ron activation by phosphorylation at Ser1394 and implications for therapeutic targeting*
**作者**：Chen L, et al.
**摘要**：通过晶体学分析，阐明了Ron受体Ser1394磷酸化对其激酶结构域的构象影响，并利用Phospho-Ser1394抗体证明该位点磷酸化与结肠癌细胞耐药性相关。
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3. **文献名称**：*A phospho-specific antibody for Ron Ser1394 detects activation in pancreatic cancer and correlates with poor prognosis*
**作者**：Wang Y, et al.
**摘要**：开发了一种高特异性Phospho-Ser1394抗体，证实其在胰腺癌组织中可作为Ron激活的生物标志物，并与患者生存率下降显著相关。
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4. **文献名称**：*Ron kinase phosphorylation at Ser1394 mediates cross-talk with EGFR signaling in lung adenocarcinoma*
**作者**：Kim T, et al.
**摘要**：研究表明，Ron的Ser1394磷酸化通过增强EGFR信号协同促进肺癌细胞侵袭，Phospho-Ser1394抗体被用于检测联合靶向治疗的潜在价值。
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**提示**：实际研究中，建议通过PubMed、Google Scholar等平台以关键词“Ron Phospho-Ser1394 antibody”或“RON S1394 phosphorylation”检索最新文献，并优先选择近5年高被引论文。
The Ron receptor tyrosine kinase, encoded by the MST1R gene, is a cell surface receptor activated by its ligand, macrophage-stimulating protein (MSP). Ron plays a role in regulating cellular processes such as proliferation, migration, and survival, particularly in epithelial and immune cells. Dysregulation of Ron signaling is implicated in cancer progression, including tumor invasion, metastasis, and resistance to apoptosis. Phosphorylation at specific residues, such as Ser1394. is critical for Ron activation and downstream signaling. The phosphorylation event at Ser1394 occurs in the kinase domain of Ron, facilitating conformational changes necessary for full receptor activation and recruitment of downstream effectors like MAPK, PI3K/Akt, and β-catenin pathways.
The Ron (Phospho-Ser1394) antibody is a monoclonal or polyclonal tool designed to specifically detect Ron phosphorylated at serine 1394. It is widely used in research to study Ron activation dynamics in physiological and pathological contexts, such as cancer, inflammation, and tissue repair. By enabling the detection of activated Ron in techniques like Western blotting, immunohistochemistry, or immunofluorescence, this antibody helps elucidate mechanisms of Ron-driven oncogenesis and evaluate therapeutic interventions targeting Ron signaling. Its specificity for the phosphorylated form ensures accurate assessment of receptor activation status, making it valuable for both basic research and drug development studies.
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