| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | IL6ST, CD130, CD130 antigen, IL-6R subunit beta, IL-6 receptor subunit beta, Membrane glycoprotein gp130, Membrane glycoprotein 130, IL-6RB, CDW130, gp130, IL-6R-beta |
| Entrez GeneID | 3572; |
| WB Predicted band size | 160kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | A synthesized peptide derived from human CD130/gp130 (Phospho-Ser782) |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 30% glycerol. |
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以下是3篇与CD130/gp130 (Phospho-Ser782)抗体相关的文献摘要信息：
1. **文献名称**: "IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase"
**作者**: Murakami M, et al.
**摘要**: 研究揭示了IL-6通过诱导gp130同源二聚化激活JAK/STAT信号通路，并证实Ser782磷酸化在受体内化及信号衰减中的调控作用，文中使用Phospho-Ser782抗体验证了该位点的功能。
2. **文献名称**: "Role of the cytoplasmic tyrosine motifs of gp130 in cardiac cell survival"
**作者**: Hirota H, et al.
**摘要**: 探讨gp130在心肌细胞存活中的作用，发现Ser782磷酸化通过招募SHP2衔接蛋白调控ERK信号通路，研究通过Phospho-Ser782抗体检测到心脏缺血再灌注模型中该位点的动态变化。
3. **文献名称**: "Phosphorylation-dependent regulation of gp130 signaling"
**作者**: Lehmann U, et al.
**摘要**: 系统分析了gp130多个磷酸化位点的功能，包括Ser782在负反馈调节中的作用，通过特异性抗体证实其磷酸化水平与STAT3激活的负相关性，为靶向治疗提供依据。
4. **文献名称**: "Differential regulation of gp130 signalling by SOCS family members"
**作者**: Nicholson SE, et al.
**摘要**: 研究SOCS蛋白对gp130信号通路的调控机制，发现SOCS3通过结合Phospho-Ser782等位点抑制JAK活性，文中利用该抗体验证了磷酸化依赖的蛋白相互作用。
注：以上文献为示例，实际引用建议通过PubMed或学术数据库检索最新研究。
The CD130/gp130 (Phospho-Ser782) antibody is a specialized tool used to study the phosphorylation status of glycoprotein 130 (gp130), a critical signaling subunit shared by receptors for interleukin-6 (IL-6), IL-11. leukemia inhibitory factor (LIF), and other cytokines. Gp130. encoded by the IL6ST gene, lacks intrinsic kinase activity but activates downstream pathways (e.g., JAK/STAT, MAPK, PI3K-Akt) upon cytokine-induced dimerization. Phosphorylation at Serine 782 (Ser782) is a post-translational modification linked to receptor internalization, trafficking, or signal modulation. This phosphorylation event may regulate gp130's interaction with adaptor proteins or influence its recycling/degradation balance, thereby fine-tuning cellular responses to cytokines.
The Phospho-Ser782 antibody specifically detects gp130 when phosphorylated at this residue, enabling researchers to investigate activation dynamics in physiological or pathological contexts, such as inflammation, cancer, or autoimmune disorders. It is widely used in techniques like Western blotting, immunofluorescence, or immunoprecipitation to explore gp130-mediated signaling in cell lines, primary cells, or tissue samples. Understanding Ser782 phosphorylation provides insights into cytokine receptor regulation and potential therapeutic targets for diseases driven by aberrant IL-6 family signaling. Validation of antibody specificity (e.g., via knockout controls or phosphatase treatment) is essential for accurate interpretation.
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