Rabbit Polyclonal Gz-α(Phospho-Ser16) Antibody

The Gz-α (Phospho-Ser16) antibody is a specialized immunological tool designed to detect the phosphorylated form of Granzyme A (GZMA) at serine residue 16. Granzyme A, a serine protease predominantly expressed in cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells, plays a critical role in inducing apoptosis in target cells during immune responses. Phosphorylation at Ser16 is a post-translational modification thought to regulate its enzymatic activity, intracellular trafficking, or interaction with other proteins, though the precise functional implications remain under investigation. This antibody is particularly useful in studies focusing on the activation status of immune cells, as phosphorylation events often correlate with cellular activation or functional modulation. Researchers employ the Gz-α (Phospho-Ser16) antibody in techniques such as Western blotting, immunohistochemistry, or flow cytometry to assess Granzyme A activation in contexts like viral infections, cancer immunotherapy, or autoimmune disorders. Its specificity for the phosphorylated epitope allows differentiation between active and inactive forms of the protein, providing insights into cytotoxic lymphocyte function and immune signaling pathways. Validation typically includes testing in knockout models or phosphorylation-deficient mutants to confirm specificity.