| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | RGS19, GNAI3IP, G alpha interacting protein, G-alpha-interacting protein, RGSGAIP, GAIP |
| Entrez GeneID | 10287; |
| WB Predicted band size | 25kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human GAIP (Phospho-Ser151) |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 30% glycerol. |
+ +
以下是关于GAIP (Phospho-Ser151)抗体的虚构参考文献示例(内容为模拟创作，非真实文献)：
1. **文献名称**：*Phosphorylation of GAIP at Ser151 regulates G protein-coupled receptor signaling*
**作者**：Bunemann, M. et al.
**摘要**：本研究揭示了GAIP蛋白在Ser151位点的磷酸化对其调控G蛋白信号的关键作用。通过Phospho-Ser151特异性抗体，作者发现该修饰增强GAIP与Gα亚基的结合能力，从而加速GTP水解并抑制下游信号传导。
2. **文献名称**：*RGS19 (GAIP) phosphorylation dynamics in cellular stress response*
**作者**：Hollinger, S. et al.
**摘要**：利用Phospho-Ser151抗体，作者证明GAIP在细胞应激(如氧化应激)中发生特异性磷酸化，导致其亚细胞定位改变，并增强对MAPK信号通路的负调控作用，揭示了其在应激适应中的新功能。
3. **文献名称**：*Structural basis of GAIP phospho-regulation at Ser151*
**作者**：De Vries, L. et al.
**摘要**：通过晶体结构分析和Phospho-Ser151抗体验证，本文阐明了Ser151磷酸化诱导GAIP构象变化，促进其与膜受体复合物的相互作用，为设计靶向该位点的调控分子提供了结构基础。
4. **文献名称**：*Development and validation of a phosphospecific antibody for GAIP Ser151*
**作者**：Wang, Q. et al.
**摘要**：本文报道了一种高特异性Phospho-Ser151抗体的开发，并通过免疫印迹和免疫荧光验证其在检测内源性GAIP磷酸化中的应用，证实其在多种细胞模型中的可靠性。
注：以上文献信息为示例性虚构内容，实际研究中需查阅真实数据库(如PubMed)获取准确文献。
The GAIP (G Alpha Interacting Protein), also known as RGS19. is a member of the Regulator of G-protein Signaling (RGS) family, primarily known for its role in downregulating G-protein-coupled receptor (GPCR) signaling. It acts as a GTPase-activating protein (GAP) for Gαi subunits, accelerating GTP hydrolysis to terminate signaling. Phosphorylation at specific residues, such as Serine 151 (Ser151), modulates GAIP's activity, stability, or interactions within signaling pathways. The phosphorylation of Ser151 is implicated in regulating GAIP’s function in cellular processes like vesicle trafficking, receptor internalization, and signal transduction.
The GAIP (Phospho-Ser151) antibody is a specialized tool designed to detect GAIP specifically phosphorylated at Ser151. This post-translational modification may influence GAIP’s interaction with binding partners or its subcellular localization, impacting its regulatory effects on GPCR pathways. Researchers utilize this antibody in techniques like Western blotting, immunofluorescence, or immunoprecipitation to study phosphorylation-dependent mechanisms in physiological or disease contexts, such as cancer or neurological disorders where dysregulated GPCR signaling is prevalent.
Understanding GAIP phosphorylation dynamics provides insights into cellular signaling fidelity and therapeutic targeting. The GAIP (Phospho-Ser151) antibody thus serves as a critical reagent for dissecting context-specific regulatory networks involving RGS proteins and GPCR signaling cascades.
×
