| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | MAZ, Pur-1, SAF-2, SAF-3, MAZI, ZF87, Zif87, ZNF801, Transcription factor Zif87, Zinc finger protein 801, PUR1, SAF-1 |
| Entrez GeneID | 4150; |
| WB Predicted band size | 48kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human MAZ (Phospho-Thr72) |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于MAZ (Phospho-Thr72)抗体的3篇参考文献的简要概括(注：文献信息为虚构示例，实际引用需核实)：
1. **文献名称**：*Phosphorylation of MAZ at Thr72 Modulates Transcriptional Activity in Cancer Cells*
**作者**：Smith A, et al.
**摘要**：本研究揭示了MAZ蛋白Thr72位点的磷酸化通过增强其与DNA启动子区域的结合能力，促进下游癌基因(如c-MYC)的表达，使用Phospho-Thr72特异性抗体验证了该修饰在肿瘤细胞中的功能。
2. **文献名称**：*MAPK Signaling Regulates MAZ via Thr72 Phosphorylation*
**作者**：Lee C, et al.
**摘要**：通过免疫印迹和免疫荧光实验(使用Phospho-Thr72抗体)，作者证明MAPK通路激活后诱导MAZ Thr72磷酸化，进而调控细胞周期相关基因的转录，影响肿瘤增殖。
3. **文献名称**：*A Phospho-Specific Antibody Reveals MAZ Thr72 Phosphorylation in Neurodegeneration*
**作者**：Wang D, et al.
**摘要**：利用Phospho-Thr72抗体，研究发现阿尔茨海默病模型中MAZ的Thr72磷酸化水平异常升高，可能导致神经元凋亡相关基因的失调，为病理机制提供了新见解。
如需具体文献，建议通过PubMed或抗体供应商提供的引用列表进一步检索。
The MAZ (Myc-associated zinc-finger protein) antibody targeting the phosphorylated Thr72 residue is a specialized tool for studying the post-translational modification of the MAZ transcription factor. MAZ, a DNA-binding protein with zinc finger motifs, regulates transcription of genes like MYC and CCND1. influencing cell proliferation, apoptosis, and differentiation. Phosphorylation at Thr72 modulates MAZ activity by altering its DNA-binding affinity, protein-protein interactions, or subcellular localization, often in response to signaling pathways like MAPK or PKC. This modification is implicated in disease contexts, including cancer and cardiovascular disorders, where dysregulated MAZ activity contributes to pathological gene expression.
The MAZ (Phospho-Thr72) antibody enables specific detection of this activated form in techniques such as Western blotting, immunofluorescence, or ChIP assays. Its utility lies in elucidating MAZ’s role in signaling cascades, cellular stress responses, or transcriptional networks. Researchers employ it to explore context-dependent regulatory mechanisms, such as MAZ’s dual role as a transcriptional activator/repressor or its crosstalk with oncogenic pathways. Validation via knockout/knockdown controls or phosphatase treatment ensures specificity. This antibody is critical for dissecting MAZ’s phosphorylation-dependent functions in both physiological and disease models.
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