首页 / 产品 / 抗体 / 一抗

Rabbit Polyclonal USF1(Phospho-Thr153) Antibody

  • 中文名: USF1 (Phospho-Thr153)抗体
  • 别    名: USF1, BHLHb11, FCHL, FCHL1, MLTFI, USF, UEF, HYPLIP1, MLTF, Upstream stimulatory factor 1
货号: IPDX41119
Price: ¥1280
数量:
大包装询价

验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesUSF1, BHLHb11, FCHL, FCHL1, MLTFI, USF, UEF, HYPLIP1, MLTF, Upstream stimulatory factor 1
Entrez GeneID7391;
WB Predicted band size34kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human USF1 (Phospho-Thr153)
FormulationPurified antibody in PBS with 0.05% sodium azide.

+ +

参考文献

以下是关于USF1 (Phospho-Thr153)抗体的模拟参考文献示例(注:内容为虚构,仅供格式参考):

1. **文献名称**:*Phosphorylation of USF1 at Thr153 Modulates Lipid Metabolism in Hepatocytes*

**作者**:Zhang, L. et al.

**摘要**:本研究揭示了USF1在Thr153位点的磷酸化通过调控脂质合成相关基因表达影响肝脏代谢。通过特异性Phospho-Thr153抗体,作者证实高脂饮食小鼠模型中该位点的磷酸化水平升高,并与胰岛素抵抗相关。

2. **文献名称**:*USF1 Thr153 Phosphorylation Enhances DNA Binding and Promotes Tumor Angiogenesis*

**作者**:Kim, J.H. & Patel, R.

**摘要**:文章利用Phospho-Thr153抗体进行染色质免疫沉淀(ChIP),发现磷酸化USF1在肿瘤血管生成基因启动子区的富集,表明该修饰增强了其转录活性,促进癌症进展。

3. **文献名称**:*Development of a Monoclonal Antibody Targeting USF1 Phosphorylated at Thr153 and Its Application in Neurodegenerative Models*

**作者**:Garcia, M. et al.

**摘要**:本研究报道了一种高特异性Phospho-Thr153抗体的开发与验证,并应用于阿尔茨海默病模型脑组织分析,发现USF1磷酸化与淀粉样蛋白沉积存在相关性。

4. **文献名称**:*AMPK-Mediated Phosphorylation of USF1 at Thr153 Regulates Mitochondrial Biogenesis*

**作者**:Wang, Y. et al.

**摘要**:通过Phospho-Thr153抗体检测,作者证明AMP激活蛋白激酶(AMPK)介导的USF1磷酸化促进线粒体生物合成相关基因表达,为代谢疾病治疗提供新靶点。

**注意**:以上文献为模拟示例,实际文献需通过PubMed、Web of Science等学术平台检索关键词“USF1 Phospho-Thr153 antibody”或相关信号通路(如代谢、癌症)进行查找。

背景信息

The USF1 (Phospho-Thr153) antibody is designed to detect the transcription factor Upstream Stimulatory Factor 1 (USF1) when phosphorylated at threonine 153 (Thr153). USF1. a member of the basic helix-loop-helix leucine zipper (bHLH-LZ) family, regulates gene expression by binding to E-box motifs in promoter regions. It plays critical roles in metabolic homeostasis, cell cycle control, and stress responses. Phosphorylation at Thr153 is a post-translational modification that modulates USF1 activity, potentially influencing its DNA-binding affinity, dimerization with USF2. or interactions with co-regulators. This modification may be triggered by signaling pathways such as AMP-activated protein kinase (AMPK) or other stress-responsive kinases, linking USF1 to energy-sensing mechanisms and metabolic adaptation. The USF1 (Phospho-Thr153) antibody is widely used in research to investigate USF1's regulatory roles in conditions like diabetes, obesity, and cardiovascular diseases. Its specificity enables the study of phosphorylation-dependent USF1 dynamics in cellular models or tissues, aiding in elucidating mechanisms underlying transcriptional regulation and disease pathogenesis. Validation methods, such as knockout controls or phosphatase treatment, are essential to confirm antibody specificity in experimental settings.

客户数据及评论

折叠内容

大包装询价

×