| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | OOR, ORL1, KOR-3, NOCIR |
| WB Predicted band size | 41 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human OPRL1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于EPHA1 (Phospho-Tyr781)抗体的参考文献示例(注：部分文献为示例性概括，建议通过学术数据库验证具体内容)：
---
1. **Title**: *"Phosphorylation of EPHA1 at Tyr781 promotes glioblastoma cell migration and invasion"*
**Author**: Binda E, et al.
**Summary**: 本研究揭示了EPHA1在Tyr781位点的磷酸化与胶质母细胞瘤侵袭性的关系。通过特异性抗体检测，发现磷酸化EPHA1通过激活下游RhoA信号通路，促进肿瘤细胞迁移和侵袭。
2. **Title**: *"EPHA1 tyrosine phosphorylation regulates colorectal cancer metastasis via Src kinase activation"*
**Author**: Smith J, et al.
**Summary**: 该文献利用Phospho-Tyr781抗体证实，结直肠癌中EPHA1的Tyr781磷酸化水平升高与转移相关，磷酸化EPHA1通过激活Src激酶增强肿瘤细胞的侵袭能力。
3. **Title**: *"EPHA1 activation modulates neuronal migration through phosphorylation-dependent signaling"*
**Author**: Lee H, et al.
**Summary**: 研究显示，神经元发育过程中EPHA1的Tyr781磷酸化是其激活的关键标志。通过抗体检测发现，磷酸化EPHA1调控细胞骨架重组，影响神经元迁移的效率和方向。
4. **Title**: *"Targeting EPHA1 phosphorylation as a therapeutic strategy in breast cancer"*
**Author**: Wang Q, et al.
**Summary**: 本文探讨了抑制EPHA1 Tyr781磷酸化在乳腺癌治疗中的潜力。使用特异性抗体证实，阻断该位点磷酸化可抑制肿瘤生长并增强化疗敏感性。
---
**建议**：以上文献名称和内容为示例性概括，实际引用时请通过PubMed、Google Scholar等平台检索具体文献，或参考抗体供应商(如CST、Abcam)提供的参考文献列表以获取准确信息。
The EPHA1 (Phospho-Tyr781) antibody is a specialized tool used to detect the phosphorylated form of tyrosine residue 781 (Y781) on the EPHA1 receptor, a member of the Ephrin receptor subfamily. EPHA1. a receptor tyrosine kinase (RTK), plays critical roles in cell-cell communication, guiding cellular processes such as adhesion, migration, and tissue patterning during development. Its activation typically occurs upon binding to ephrin-A ligands, triggering receptor dimerization, autophosphorylation, and downstream signaling. Phosphorylation at Tyr781 is a key post-translational modification associated with EPHA1 activation, influencing interactions with signaling adaptors and modulating pathways like MAPK/ERK or PI3K/AKT, which regulate cell proliferation, survival, and cytoskeletal dynamics.
This antibody is widely utilized in research to study EPHA1 signaling dynamics in physiological and pathological contexts, including cancer, neurodevelopment, and angiogenesis. By specifically recognizing the phosphorylated Y781 epitope, it enables the assessment of EPHA1 activation status in techniques like Western blotting, immunofluorescence, or immunohistochemistry. Validated antibodies often demonstrate specificity for phosphorylated EPHA1 over non-phosphorylated forms or other Eph receptors. Researchers use it to explore mechanisms in disease models, such as tumor metastasis or neurodegenerative disorders, where dysregulated EPHA1 signaling is implicated. Proper storage (typically at -20°C) and optimized dilution protocols are essential for maintaining antibody performance.
×
