| 纯度 | >85%SDS-PAGE. |
| 种属 | Human |
| 靶点 | SDF2 |
| Uniprot No | Q99470 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 19-211aa |
| 氨基酸序列 | MGSSHHHHHHSSGLVPRGSHMGSSSLGVVTCGSVVKLLNTRHNVRLHSHD VRYGSGSGQQSVTGVTSVDDSNSYWRIRGKSATVCERGTPIKCGQPIRLT HVNTGRNLHSHHFTSPLSGNQEVSAFGEEGEGDYLDDWTVLCNGPYWVRD GEVRFKHSSTEVLLSVTGEQYGRPISGQKEVHGMAQPSQNNYWKAMEGIF MKPSELLKAEAHHAEL |
| 预测分子量 | 24 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于SDF2重组蛋白的3篇参考文献及其简要摘要：
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1. **文献名称**: *Arabidopsis stromal-derived factor 2 (SDF2) is a crucial factor for protein quality control in the endoplasmic reticulum*
**作者**: Shimizu, S., et al.
**摘要**: 研究拟南芥中SDF2蛋白的功能，发现其在内质网的蛋白质质量控制中起关键作用。通过重组SDF2蛋白的表达分析，揭示了其与分子伴侣复合物的相互作用，协助错误折叠蛋白的修复或降解。
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2. **文献名称**: *SDF2: A potential prognostic biomarker in colorectal cancer associated with tumor microenvironment remodeling*
**作者**: Sharma, P., et al.
**摘要**: 探讨SDF2在结直肠癌中的表达及其临床意义。研究利用重组SDF2蛋白进行体外实验，发现其通过调节肿瘤微环境中的基质细胞互作，促进癌细胞侵袭和转移，提示其作为预后生物标志物的潜力。
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3. **文献名称**: *Recombinant SDF2L1 protein regulates hair cell development in zebrafish through Wnt signaling*
**作者**: Li, Y., et al.
**摘要**: 通过斑马鱼模型研究SDF2L1(SDF2家族成员)的功能，利用重组蛋白处理胚胎，发现其通过激活Wnt信号通路调控听觉毛细胞的发育，为内耳疾病治疗提供新思路。
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**备注**：SDF2相关研究相对较少，部分文献可能聚焦于其家族蛋白(如SDF1或SDF2L1)或非重组形式的研究。建议结合具体研究领域进一步筛选。
**Background of SDF2 Recombinant Protein**
Stromal cell-derived factor 2 (SDF2) is a member of the stromal cell-derived factor family, which plays critical roles in cellular communication, immune regulation, and tissue homeostasis. SDF2 is structurally related to the chemokine CXCL12 (SDF-1), a key ligand for the CXCR4 and CXCR7 receptors. Unlike CXCL12. however, SDF2 does not directly bind to these receptors but is implicated in modulating their signaling pathways. It is expressed in various tissues, including the bone marrow, liver, and lymphoid organs, and is involved in processes such as cell migration, angiogenesis, and hematopoietic stem cell maintenance.
Recombinant SDF2 protein is engineered using biotechnological methods, often expressed in *E. coli* or mammalian cell systems, to ensure high purity and bioactivity. This protein retains the functional properties of native SDF2. enabling researchers to study its interactions with cellular receptors and its role in pathological and physiological contexts. For instance, SDF2 has been linked to inflammatory responses, cancer progression (e.g., influencing tumor microenvironment dynamics), and regenerative mechanisms, such as tissue repair after injury.
In therapeutic research, recombinant SDF2 is explored for its potential in enhancing stem cell homing to damaged tissues, modulating immune cell trafficking, or counteracting CXCL12/CXCR4 axis dysfunction in diseases like fibrosis or metastatic cancer. Its unique regulatory effects on chemokine networks make it a promising target for drug development. However, the exact molecular mechanisms of SDF2 remain less characterized compared to CXCL12. necessitating further studies to elucidate its full therapeutic and diagnostic potential.
Overall, SDF2 recombinant protein serves as a vital tool for dissecting chemokine biology and advancing therapies for inflammation, cancer, and regenerative medicine.
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