Rabbit Polyclonal ADAMTSL2 Antibody

The ADAMTSL2 (A Disintegrin and Metalloproteinase with Thrombospondin Motifs-like 2) antibody is a tool used to study the ADAMTSL2 protein, a member of the ADAMTS superfamily. Unlike canonical ADAMTS proteases, ADAMTSL2 lacks a catalytic domain and functions as a secreted glycoprotein involved in extracellular matrix (ECM) organization and growth factor regulation. It interacts with fibrillin-1. a key component of microfibrils, and modulates TGF-β signaling, influencing tissue development and homeostasis. Mutations in the ADAMTSL2 gene are linked to genetic disorders such as geleophysic dysplasia and Marfan-like syndromes, characterized by skeletal abnormalities, short stature, and cardiovascular complications. The ADAMTSL2 antibody enables detection and localization of the protein in tissues and cell cultures, aiding research into its role in ECM integrity, fibrillin microfibril assembly, and disease mechanisms. Its application spans immunoblotting, immunohistochemistry, and immunofluorescence, providing insights into how ADAMTSL2 dysfunction contributes to connective tissue pathologies. Studies using this antibody have also explored its potential involvement in fibrosis and metabolic pathways, highlighting its broader relevance in developmental biology and translational medicine.