| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ANKRD20A3 |
| Uniprot No | Q5VUR7 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-823aa |
| 氨基酸序列 | MKLFGFGSRRGQTAQGSIDHVYTGSGYRIRDSELQKIHRAAVKGDAAEVERCLARRSGDLDALDKQHRTALHLACASGHVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILLEHGANPNLKDIYGNTALHYAVYSESTSLAEKLLSHGAHIEALDKDNNTPLLFAIICKKEKMVEFLLKRKASSHAVDRLRRSALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRDAEDYAISHHLTKIQQQILEHKKKILKKEKSDVGSSDESAVSIFHELRVDSLPASDDKDLNVATKQCVPEKVSEPLPGSSHEKGNRIVNGQGEGPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRAEQALPVASEEEQERHERSEKKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRKIGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNMLYKKNREELERKEKQYKKEVEAKQLEPTVQSLEMKSKTARNTPNRDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKENKYLKDIKIVKETNAALEKYIKLNEEMITETAFRYQQELNYLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAAISKHSESVKTERNLKLALERTRDVSVQVEMSSAISKVKDENEFLTEQLSETQIKFNALKDKFRKTRDSLRKKSLALETVQNDLSQTQQQTQEMKEMYQNAEAKVNNSTGKWNCVEERICHLQRENAWLVQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLVLEEKSKKLMNECDHLKESLFQYEREKTEGVVSIKEDKYFQTSRKTI |
| 分子量 | 90.6 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于ANKRD20A3的虚构参考文献示例(实际研究可能有限，建议结合具体数据库或文献平台核实)：
1. **文献名称**: *ANKRD20A3 expression in human spermatogenesis*
**作者**: Huang, L. et al. (2021)
**摘要**: 研究发现ANKRD20A3在睾丸组织特异性表达，可能通过调控染色质重塑参与精子形成过程，并可能与不育症相关。
2. **文献名称**: *Copy number variation of ANKRD20A3 in male infertility*
**作者**: Smith, R. et al. (2019)
**摘要**: 通过对不育男性基因组分析，发现ANKRD20A3所在染色体区域的拷贝数变异可能与精子形态异常相关。
3. **文献名称**: *Anchor protein repeat domains in genomic instability*
**作者**: Zhang, Q. et al. (2020)
**摘要**: 分析ANKRD家族成员结构，推测ANKRD20A3可能通过与DNA修复蛋白相互作用维持基因组稳定性。
4. **文献名称**: *Computational modeling of ANKRD20A3 protein structure*
**作者**: Kim, J. & Patel, S. (2022)
**摘要**: 利用AlphaFold预测ANKRD20A3的3D结构，揭示其锚蛋白重复序列可能参与蛋白质互作网络的构建。
**注意**：上述文献为模拟生成，实际研究中ANKRD20A3的研究报道较少，建议通过NCBI PubMed或UniProt获取最新信息。
ANKRD20A3 (Ankyrin Repeat Domain-Containing Protein 20A3) is a member of the ankyrin repeat domain (ANKRD) protein family, characterized by tandem repeats of ~33-amino-acid motifs that mediate protein-protein interactions. While its precise biological function remains incompletely understood, ANKRD20A3 is primarily expressed in the testis and has been implicated in germ cell development. The gene encoding ANKRD20A3 is located in a chromosomal region (9p24.1) associated with genomic instability and recurrent rearrangements in cancers. Unlike other ANKRD family proteins involved in apoptosis, transcriptional regulation, or inflammatory signaling, ANKRD20A3 lacks a defined functional domain beyond its ankyrin repeats, suggesting a specialized role in modulating protein complexes unique to reproductive tissues.
Recent studies highlight its potential involvement in chromatin organization and epigenetic regulation during spermatogenesis, though mechanistic insights are limited. In cancer contexts, aberrant ANKRD20A3 expression has been observed in testicular germ cell tumors, though its oncogenic or tumor-suppressive role is unclear. Recombinant forms of ANKRD20A3 are utilized in structural studies to elucidate its binding partners and conformational dynamics. Despite these efforts, the protein’s physiological and pathological significance remains understudied, warranting further investigation into its interactions with gamete-specific kinases, chromatin modifiers, or meiotic regulators. Its testis-predominant expression pattern positions it as a potential biomarker for male infertility or reproductive disorders.
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