| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ANKRD36 |
| Uniprot No | A6QL64 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-163aa |
| 氨基酸序列 | MEDGKRERWPTLMERLCSDGFAFPQYPIKPYHLKRIHRAVLHGNLEKLKYLLLTYYDANKRDRKERTALHLACATGQPEMVHLLVSRRCELNLCDREDRTPLIKAVQLRQEACATLLLQNGANPNITDFFGRTALHYAVYNEDTSMIEKLLSHGTNIEECSKV |
| 分子量 | 45.3 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于ANKRD36的模拟参考文献(仅供学术参考，建议通过数据库核实)：
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1. **文献名称**: *ANKRD36 is a novel tumor-associated biomarker with elevated expression in testicular germ cell tumors*
**作者**: Fujita K, et al.
**摘要**: 该研究通过转录组分析发现ANKRD36在睾丸生殖细胞肿瘤中显著高表达，提示其可能作为诊断标志物。进一步实验表明，ANKRD36的突变可能与肿瘤细胞增殖相关。
2. **文献名称**: *Functional characterization of ANKRD36 in cell cycle regulation*
**作者**: Wang Y, et al.
**摘要**: 研究通过CRISPR敲除技术证实ANKRD36在G1/S细胞周期检查点中的作用，发现其缺失导致周期停滞，并可能与p53通路相互作用，影响基因组稳定性。
3. **文献名称**: *Evolutionary and structural analysis of ANKRD36 across mammalian species*
**作者**: Garcia-Sanchez S, et al.
**摘要**: 分析ANKRD36基因的进化保守性，揭示其在灵长类中的特异性结构域扩展，推测其可能在免疫调节或生殖系统中具有独特功能。
4. **文献名称**: *Epigenetic silencing of ANKRD36 in hematologic malignancies*
**作者**: Li R, et al.
**摘要**: 发现血液肿瘤中ANKRD36启动子区高频甲基化导致表达下调，体外过表达实验显示其可能通过抑制NF-κB信号通路减缓肿瘤细胞生长。
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**提示**：以上为基于文献主题的模拟内容，实际文献需通过PubMed或Web of Science检索确认。
Ankyrin Repeat Domain-Containing Protein 36A (ANKRD36) is a largely uncharacterized human protein encoded by the *ANKRD36* gene. It belongs to the ankyrin repeat protein family, known for mediating protein-protein interactions via conserved tandem repeats. The *ANKRD36* gene is located on chromosome 2 (2q11.2) and produces multiple splice variants, though their biological relevance remains unclear. ANKRD36 is predominantly expressed in testis, bone marrow, and placenta, suggesting potential roles in germ cell development, hematopoiesis, or immune modulation. Despite conservation across mammals, functional studies are limited. Preliminary bioinformatic analyses indicate possible associations with cellular stress responses and inflammation due to co-expression with immune-related genes. Some studies hypothesize involvement in male fertility, as its testis-specific expression aligns with roles in spermatogenesis. Intriguingly, *ANKRD36* polymorphisms have been weakly linked to autoimmune diseases and cancers, though mechanisms are undefined. The protein lacks enzymatic domains, implying it may function as a scaffold or regulator in signaling complexes. Challenges in studying ANKRD36 include limited antibodies, tissue-specific expression, and absence of clear homologs in model organisms. Current research focuses on identifying interaction partners and validating its physiological context through omics approaches. Further investigation is needed to elucidate its molecular mechanisms and potential therapeutic relevance.
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