| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ARL6IP2 |
| Uniprot No | Q8NHH9 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-412aa |
| 氨基酸序列 | MDTQGAFDSQSTIKDCATVFALSTMTSSVQVYNLSQNIQEDDLQHLQLFTEYGRLAMEEIYQKPFQTLMFLIRDWSYPYEHSYGLEGGKQFLEKRLQVKQNQHEELQNVRKHIHNCFSNLGCFLLPHPGLKVATNPSFDGRLKDIDEDFKRELRNLVPLLLAPENLVEKEISGSKVTCRDLVEYFKAYIKIYQGEELPHPKSMLQATAEANNLAAVAGARDTYCKSMEQVCGGDKPYIAPSDLERKHLDLKEVAIKQFRSVKKMGGDEFCRRYQDQLEAEIEETYANFIKHNDGKNIFYAARTPATLFAVMFAMYIISGLTGFIGLNSIAVLCNLVMGLALIFLCTWAYVKYSGEFREIGTVIDQIAETLWEQVLKPLGDNLMEENIRQSVTNSIKAGLTDQVSHHARLKTD |
| 分子量 | 71.06 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
1. **文献名称**: "ARL6IP2 mediates cisplatin-induced apoptosis in cervical cancer cells through regulation of Bcl-2 family proteins"
**作者**: Li, X., et al.
**摘要**: 研究揭示了ARL6IP2在宫颈癌细胞凋亡中的调控作用，发现过表达ARL6IP2通过下调抗凋亡蛋白Bcl-2并激活Caspase通路增强顺铂的细胞毒性。
2. **文献名称**: "Crystal structure of human ARL6IP2 reveals a conserved role in membrane dynamics"
**作者**: Zhang, Y., et al.
**摘要**: 首次解析了ARL6IP2蛋白的晶体结构，表明其通过N端螺旋结构域与内质网膜互作，提示其在囊泡运输或膜重塑中的潜在功能。
3. **文献名称**: "ARL6IP2 interacts with TDP-43 and regulates its cytoplasmic aggregation in ALS models"
**作者**: Watanabe, S., et al.
**摘要**: 发现ARL6IP2与渐冻症(ALS)关键蛋白TDP-43结合，抑制其异常胞质聚集，为神经退行性疾病机制提供了新的分子靶点。
4. **文献名称**: "Systematic analysis of ARL6IP2 in metabolic regulation using a knockout mouse model"
**作者**: Chen, L., et al.
**摘要**: 通过基因敲除小鼠模型证明ARL6IP2缺失导致线粒体形态异常和脂肪酸氧化缺陷，表明其在代谢稳态中的关键作用。
---
注：上述文献信息为基于领域知识生成的示例，实际引用需通过学术数据库核实具体研究内容。如需查询真实文献，建议使用PubMed、Web of Science等平台检索“ARL6IP2”。
ARL6IP2 (ADP-ribosylation factor-like 6 interacting protein 2) is a member of the ARL protein family, which shares structural homology with ADP-ribosylation factors (ARFs) involved in membrane trafficking and cytoskeletal regulation. This protein is encoded by the ARL6IP2 gene located on human chromosome 1p36.33. Predominantly expressed in the brain, kidney, and liver, ARL6IP2 contains conserved transmembrane domains and a C-terminal coiled-coil region, suggesting roles in intracellular protein transport or organelle dynamics. It interacts with ARL6. a GTPase linked to ciliary function and neurodevelopment, and may regulate vesicle trafficking or endoplasmic reticulum (ER)-related processes such as apoptosis and lipid metabolism. Studies implicate ARL6IP2 in neurological disorders, including hereditary spastic paraplegia, and cancer progression due to its anti-apoptotic properties. Recombinant ARL6IP2 protein, often produced in E. coli or mammalian systems, enables structural studies, interaction assays, and functional investigations. Its overexpression in tumor cells has been associated with chemoresistance, highlighting potential therapeutic relevance. However, its precise molecular mechanisms and tissue-specific functions remain under active investigation, particularly in neurodevelopment and metabolic regulation.
×
