| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ARMCX5 |
| Uniprot No | Q6P1M9 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-558aa |
| 氨基酸序列 | MVDSGTEARA RGKAEAGLQD GISGPATARV NGKTQAEAVA EAELKTESVT QAKAGDGAMT RTHTVTYREA MAVTREVIKV EDTTKTRVMV ETKTKPLAER SIVPQTKSKA MPMSRVSTVT KSEVKVVAVI EANIRSYAKS HDKANTGSRP DRREETSIGM KSSDEDEENI CSWFWTGEEP SVGSWFWPEE ETSLQVYKPL PKIQEKPKPT HKPTLTIKQK VIAWSRARYI VLVPVEGGEQ SLPPEGNWTL VETLIETPLG IRPLTKIPPY HGPYYQTLAE IKKQIRQREK YGPNPKACHC KSRGFSLEPK EFDKLVALLK LTKDPFIHEI ATMIMGISPA YPFTQDIIHD VGITVMIENL VNNPNVKEHP GALSMVDDSS ESSEEPKSGE SYIHQVCKGI ISCPLNSPVQ LAGLKLLGHL SIKFEDHYVI TSYIPDFLTL LNKGSVKTKF YVLKVFSCLS KNHANTRELI SAKVLSSLVA PFNKNESKAN ILNIIEIFEN INFQFKTKAK LFTKEKFTKS ELISIFQEAK QFGQKLQDLA EHSDPEVRDK VIRLILKL |
| 分子量 | 62.3 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下为基于现有知识构建的3篇关于 **ARMCX5(Armadillo Repeat Containing X-Linked Protein 5)** 的模拟参考文献示例(注：实际文献可能需要通过PubMed/Google Scholar检索)：
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1. **文献名称**: *ARMCX5 regulates mitochondrial dynamics and neuronal development through interaction with MIRO proteins*
**作者**: Doe J. et al.
**摘要内容**：
本文发现ARMCX5通过结合线粒体转运蛋白MIRO1/2调控线粒体在神经元中的分布和运输，基因敲除导致小鼠神经元突触发育异常，提示ARMCX5在神经系统发育中的关键作用。
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2. **文献名称**: *ARMCX5 acts as a tumor suppressor in gastric cancer by modulating Wnt/β-catenin signaling*
**作者**: Zhang L. et al.
**摘要内容**：
研究显示ARMCX5在胃癌组织中表达下调，其过表达可抑制肿瘤细胞增殖和转移。机制研究表明，ARMCX5通过拮抗β-catenin核转位抑制Wnt通路活性，具有潜在的抑癌功能。
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3. **文献名称**: *Systematic analysis of the ARMCX family reveals ARMCX5 involvement in cancer cell migration*
**作者**: Smith R. et al.
**摘要内容**：
本文系统分析了ARMCX家族成员的表达及功能，发现ARMCX5在多种癌细胞中与细胞迁移相关。沉默ARMCX5显著抑制细胞骨架重塑，提示其通过调控细胞黏附途径促进侵袭。
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**说明**：
以上文献为模拟生成，真实文献需通过学术数据库检索。ARMCX5的研究多聚焦于其在 **线粒体调控、癌症** 及 **神经系统** 中的分子机制，实际应用中建议结合最新文献进行验证。
ARMCX5 (Armadillo Repeat Containing X-Linked 5) is a member of the ARMCX protein family, encoded by genes located on the X chromosome. This family is characterized by armadillo (ARM) repeat domains, which mediate protein-protein interactions and play roles in diverse cellular processes. ARMCX5. like other ARMCX members, is evolutionarily conserved and shares structural homology with the *armadillo* gene in *Drosophila*, involved in developmental signaling pathways.
Though the precise functions of ARMCX5 remain incompletely understood, studies suggest its involvement in mitochondrial dynamics, intracellular transport, and apoptosis regulation. It is postulated to interact with mitochondrial membrane components, influencing energy metabolism and cellular stress responses. Emerging evidence links ARMCX5 to neurological disorders and cancer. For instance, abnormal expression levels have been observed in gliomas and neurodevelopmental conditions, hinting at potential roles in tumorigenesis or neural maintenance.
ARMCX5 is predominantly expressed in the brain, testis, and other metabolically active tissues, suggesting tissue-specific regulatory mechanisms. Its X-chromosome localization raises questions about sex-based differences in disease susceptibility or progression. However, detailed molecular mechanisms and physiological relevance remain under investigation, partly due to functional redundancy within the ARMCX family. Recent studies using knockdown models indicate that ARMCX5 deficiency may impair mitochondrial morphology and autophagy, further highlighting its importance in cellular homeostasis. Further research is needed to elucidate its exact biological pathways and therapeutic potential.
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