| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ARTS1 |
| Uniprot No | Q9NZ08 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-941aa |
| 氨基酸序列 | MVFLPLKWSLATMSFLLSSLLALLTVSTPSWCQSTEASPKRSDGTPFPWNKIRLPEYVIPVHYDLLIHANLTTLTFWGTTKVEITASQPTSTIILHSHHLQISRATLRKGAGERLSEEPLQVLEHPRQEQIALLAPEPLLVGLPYTVVIHYAGNLSETFHGFYKSTYRTKEGELRILASTQFEPTAARMAFPCFDEPAFKASFSIKIRREPRHLAISNMPLVKSVTVAEGLIEDHFDVTVKMSTYLVAFIISDFESVSKITKSGVKVSVYAVPDKINQADYALDAAVTLLEFYEDYFSIPYPLPKQDLAAIPDFQSGAMENWGLTTYRESALLFDAEKSSASSKLGITMTVAHELAHQWFGNLVTMEWWNDLWLNEGFAKFMEFVSVSVTHPELKVGDYFFGKCFDAMEVDALNSSHPVSTPVENPAQIREMFDDVSYDKGACILNMLREYLSADAFKSGIVQYLQKHSYKNTKNEDLWDSMASICPTDGVKGMDGFCSRSQHSSSSSHWHQEGVDVKTMMNTWTLQKGFPLITITVRGRNVHMKQEHYMKGSDGAPDTGYLWHVPLTFITSKSDMVHRFLLKTKTDVLILPEEVEWIKFNVGMNGYYIVHYEDDGWDSLTGLLKGTHTAVSSNDRASLINNAFQLVSIGKLSIEKALDLSLYLKHETEIMPVFQGLNELIPMYKLMEKRDMNEVETQFKAFLIRLLRDLIDKQTWTDEGSVSERMLRSQLLLLACVHNYQPCVQRAEGYFRKWKESNGNLSLPVDVTLAVFAVGAQSTEGWDFLYSKYQFSLSSTEKSQIEFALCRTQNKEKLQWLLDESFKGDKIKTQEFPQILTLIGRNPVGYPLAWQFLRKNWNKLVQKFELGSSSIAHMVMGTTNQFSTRTRLEEVKGFFSSLKENGSQLRCVQQTIETIEENIGWMDKNFDKIRVWLQSEKLERM |
| 分子量 | 107 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人ARTS1蛋白的示例参考文献(注：文献为虚构示例，供格式参考)：
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1. **文献名称**: *ARTS1 regulates TNF-α shedding through metalloprotease-dependent pathways*
**作者**: Savarian, E., et al.
**摘要**: 研究揭示了ARTS1作为锌金属蛋白酶在调控TNF-α释放中的关键作用，通过切割膜结合型TNF-α促进其可溶性形式分泌，影响炎症反应。
2. **文献名称**: *Structural insights into the catalytic mechanism of human ARTS1 aminopeptidase*
**作者**: Cui, L., et al.
**摘要**: 通过X射线晶体学解析了ARTS1的三维结构，阐明了其底物结合口袋与催化锌离子的作用机制，为靶向药物设计提供依据。
3. **文献名称**: *ARTS1 mediates antigen processing by trimming MHC class I-presented peptides*
**作者**: Fang, H., et al.
**摘要**: 探讨ARTS1在内质网中修剪MHC I类分子结合多肽的功能，证明其在适应性免疫应答中的关键调控作用。
4. **文献名称**: *ARTS1 promotes apoptosis in cancer cells via mitochondrial pathways*
**作者**: Becker, K., et al.
**摘要**: 发现ARTS1通过激活线粒体凋亡通路抑制肿瘤生长，其表达水平与癌症患者预后显著相关。
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如需真实文献，建议通过PubMed或Google Scholar以“ARTS1 protein”“aminopeptidase ARTS1”等关键词检索。
Recombinant human ARTS1 (ADAMTS18) protein is a member of the ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) family, which comprises extracellular proteases involved in tissue remodeling, inflammation, and angiogenesis. ARTS1. encoded by the ADAMTS18 gene, contains a conserved modular structure including a propeptide, metalloproteinase, disintegrin-like, and thrombospondin type-1 domains. It plays a role in hydrolyzing extracellular matrix (ECM) components and regulating cellular interactions through proteolytic processing of substrates like aggrecan, versican, and growth factors.
Functionally, ARTS1 is implicated in diverse physiological and pathological processes. Studies suggest its involvement in organ development, hematopoiesis, and tumor suppression, with dysregulation linked to cancers, cardiovascular diseases, and inflammatory disorders. Notably, ARTS1 exhibits anti-angiogenic properties by modulating VEGF signaling, highlighting therapeutic potential in cancer and ocular diseases.
Recombinant ARTS1 is produced via mammalian or bacterial expression systems, enabling structural and functional studies. Its purified form facilitates research into enzyme-substrate interactions, inhibitor screening, and mechanistic insights into ECM dynamics. Despite progress, ARTS1's full biological spectrum and regulatory networks remain under investigation, necessitating further exploration of its pathophysiological roles and therapeutic applications.
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