| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C18orf56 |
| Uniprot No | Q8TAI1 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-123aa |
| 氨基酸序列 | MTPASGATAS LGRLRARPRS RWDAAYLPAV AAVCVARASH VPNGTLRFGV CKARRTMRPL PRRIEVRTKR GPQRPAAPER SPQPRLPPSR HPSRRGPRRH LSGCSAPACR IPTGCRCPCG RPS |
| 分子量 | 13.6 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C18orf56(URI1)蛋白的3篇参考文献示例(注：文献为模拟概括，实际研究需根据具体数据库查询)：
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1. **名称**: *C18orf56 encodes a protein interacting with the RNA polymerase II subunit RPB5*
**作者**: Smith J et al.
**摘要**: 研究通过重组人C18orf56蛋白表达，发现其与RNA聚合酶II亚基RPB5直接相互作用，提示其在转录调控中的潜在作用。
2. **名称**: *Structural characterization of the URI1 protein and its role in mTOR signaling*
**作者**: Lee H et al.
**摘要**: 利用重组C18orf56蛋白进行晶体结构解析，揭示其作为分子伴侣通过mTOR通路调控细胞代谢的功能机制。
3. **名称**: *C18orf56 knockdown impairs mitochondrial function via HSP90 interaction*
**作者**: García-Ruiz C et al.
**摘要**: 通过重组蛋白实验证实C18orf56与HSP90的互作，调控线粒体应激反应，影响癌细胞存活。
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如需真实文献，建议通过PubMed、Google Scholar等平台检索“C18orf56”(或别名URI1)结合关键词“recombinant protein”或“functional study”。
The human C18orf56 protein, encoded by the chromosome 18 open reading frame 56 gene, is a poorly characterized protein with limited functional information. It is conserved across vertebrates but lacks well-defined structural or functional domains in most databases. Predicted to contain intrinsically disordered regions, C18orf56 may participate in transient protein interactions. Subcellular localization studies suggest nuclear or cytoplasmic presence, with nuclear localization signals hinting at potential roles in DNA-related processes. Some studies link C18orf56 to cell cycle regulation, DNA damage response, or transcriptional regulation, though experimental validation is scarce. Its expression varies across tissues, with higher levels observed in the liver, kidneys, and brain. Disease associations remain tentative, with sporadic reports suggesting possible involvement in glioblastoma, hepatocellular carcinoma, or autoimmune disorders. Recombinant C18orf56 protein production enables antibody development and interaction studies, yet biochemical properties like enzymatic activity remain unknown. Current research focuses on clarifying its interactome and mechanistic contributions to cellular pathways. The protein's low sequence complexity and lack of homology to well-studied proteins pose challenges for functional prediction, making it a potential target for exploratory studies in fundamental cell biology.
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