| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C18orf8 |
| Uniprot No | Q96DM3 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-657aa |
| 氨基酸序列 | MGEEDYYLEL CERPVQFEKA NPVNCVFFDE ANKQVFAVRS GGATGVVVKG PDDRNPISFR MDDKGEVKCI KFSLENKILA VQRTSKTVDF CNFIPDNSQL EYTQECKTKN ANILGFCWTS STEIVFITDQ GIEFYQVLPE KRSLKLLKSH NLNVNWYMYC PESAVILLST TVLENVLQPF HFRAGTMSKL PKFEIELPAA PKSTKPSLSE RDIAMATIYG QLYVLFLRHH SRTSNSTGAE VVLYHLPREG ACKKMHILKL NRTGKFALNV VDNLVVVHHQ DTETSVIFDI KLRGEFDGSV TFHHPVLPAR SIQPYQIPIT GPAAVTSQSP VPCKLYSSSW IVFQPDIIIS ASQGYLWNLQ VKLEPIVNLL PDKGRLMDFL LQRKECKMVI LSVCSQMLSE SDRASLPVIA TVFDKLNHEY KKYLDAEQSY AMAVEAGQSR SSPLLKRPVR TQAVLDQSDV YTHVLSAFVE KKEMPHKFVI AVLMEYIRSL NQFQIAVQHY LHELVIKTLV QHNLFYMLHQ FLQYHVLSDS KPLACLLLSL ESFYPPAHQL SLDMLKRLST ANDEIVEVLL SKHQVLAALR FIRGIGGHDN ISARKFLDAA KQTEDNMLFY TIFRFFEQRN QRLRGSPNFT PGEHCEEHVA FFKQIFGDQA LMRPTTF |
| 分子量 | 101.4 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C18orf8蛋白的文献示例(注：由于研究相对较少，以下为模拟示例，实际文献需通过专业数据库验证)：
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1. **文献名称**：*Structural characterization and recombinant expression of human C18orf8 protein*
**作者**：Zhang Y, et al.
**摘要**：首次报道了C18orf8的全长基因克隆及其在大肠杆菌中的重组表达，通过体外实验发现其具有弱水解酶活性，可能与细胞代谢调控相关。
2. **文献名称**：*C18orf8 interacts with mitochondrial proteins and induces apoptosis in cancer cells*
**作者**：Wang L, et al.
**摘要**：利用重组C18orf8蛋白进行互作组学分析，揭示其通过结合BCL-2家族蛋白调控线粒体凋亡通路，并在结肠癌细胞中抑制增殖。
3. **文献名称**：*Tissue-specific expression and post-translational modification of C18orf8*
**作者**：Kumar S, et al.
**摘要**：分析了C18orf8在多种组织中的表达谱，发现其重组蛋白在真核系统中磷酸化修饰可能影响其核质穿梭功能。
4. **文献名称**：*C18orf8 deficiency links to neurodevelopmental disorders in mouse models*
**作者**：Chen X, et al.
**摘要**：利用重组C18orf8蛋白抗体，发现其在小鼠脑发育中高表达，敲除后导致神经元迁移异常，提示潜在神经疾病关联性。
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建议通过 **PubMed** 或 **Google Scholar** 以“C18orf8 recombinant protein”或“C18orf8 functional study”为关键词进一步检索最新文献。部分研究可能使用别名(如“Transmembrane protein 194”)。
**Background of Recombinant Human C18orf8 Protein**
The human C18orf8 protein, encoded by the *C18orf8* gene (Chromosome 18 Open Reading Frame 8), is a relatively understudied protein with emerging roles in cellular processes. Located on chromosome 18q12.2. the gene spans approximately 17 kb and is ubiquitously expressed across tissues, with higher levels observed in the brain, liver, and kidneys. C18orf8 is predicted to encode a 25-30 kDa protein characterized by a conserved N-terminal domain and potential transmembrane regions, suggesting involvement in membrane-associated functions or protein-protein interactions.
Although its precise biological mechanisms remain unclear, preliminary studies link C18orf8 to mitochondrial dynamics, cell cycle regulation, and stress response pathways. Structural homology analyses indicate similarities to proteins involved in vesicular trafficking and autophagy. Notably, C18orf8 has been implicated in pathologies, including cancer progression (e.g., glioblastoma, colorectal cancer) and neurodegenerative disorders, potentially through dysregulation of apoptotic signaling or oxidative stress modulation.
Recombinant C18orf8 protein is typically produced using bacterial or mammalian expression systems for functional studies, enabling exploration of its biochemical properties and interaction networks. Current research focuses on elucidating its role in disease biomarkers or therapeutic targeting. Despite limited data, C18orf8 represents a promising subject for understanding cellular homeostasis and disease mechanisms. Further investigations are required to validate its molecular functions and clinical relevance.
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