| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CXorf48 |
| Uniprot No | Q8WUE5 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-264aa |
| 氨基酸序列 | MLRLLRLALA FYGRTADPAE RQGPQQQGLP QGDTQLTTVQ GVVTSFCGDY GMIDESIYFS SDVVTGNVPL KVGQKVNVVV EEDKPHYGLR AIKVDVVPRH LYGAGPSDSG TRVLIGCVTS INEDNIYISN SIYFSIAIVS EDFVPYKGDL LEVEYSTEPG ISNIKATSVK PIRCIHTEEV CITSVHGRNG VIDYTIFFTL DSVKLPDGYV PQVDDIVNVV MVESIQFCFI WRAISITPVH KSSSGFQDDG GLGRPKRERR SQSI |
| 分子量 | 55.5 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是3-4条关于重组人CXorf48蛋白的示例参考文献(注：以下文献为虚构示例，实际研究中请查询具体数据库)：
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1. **文献名称**: "Functional characterization of recombinant human CXorf48 protein in cellular apoptosis regulation"
**作者**: Li et al. (2022)
**摘要**: 本研究成功构建了重组人CXorf48蛋白的真核表达系统，并通过体外功能实验发现其在HeLa细胞中显著抑制化疗药物诱导的凋亡，提示CXorf48可能作为肿瘤细胞抗凋亡因子的潜在作用。
2. **文献名称**: "Structural and biochemical analysis of human CXorf48 protein reveals a novel DNA-binding motif"
**作者**: Smith & Johnson (2021)
**摘要**: 采用X射线晶体学解析重组CXorf48蛋白的三维结构，发现其N端存在独特的α-螺旋-转角结构域，并通过凝胶迁移实验证实该结构域能特异性结合特定双链DNA序列，可能参与基因表达调控。
3. **文献名称**: "CXorf48 interacts with the mTOR signaling pathway: Insights from recombinant protein-based interaction assays"
**作者**: Wang et al. (2020)
**摘要**: 通过重组CXorf48蛋白的Pull-down联合质谱分析，鉴定出mTOR复合体相关蛋白为其相互作用靶点，并发现CXorf48过表达可增强mTORC1活性，提示其在代谢调控通路中的作用。
4. **文献名称**: "CXorf48 recombinant protein-based biomarker screening in colorectal cancer"
**作者**: García-Sánchez et al. (2019)
**摘要**: 利用原核表达系统制备重组CXorf48蛋白，开发ELISA检测方法用于筛查结直肠癌患者血清中的特异性抗体，结果显示CXorf48抗体阳性率与晚期肿瘤转移显著相关。
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**注意**：以上文献信息均为虚构案例，真实研究需通过PubMed、Web of Science等数据库以关键词"CXorf48"、"recombinant CXorf48"等进行检索。
Human CXorf48 (chromosome X open-reading frame 48) is a protein encoded by a gene located on the X chromosome. While its exact biological function remains incompletely characterized, emerging studies suggest potential roles in cellular processes such as proliferation, apoptosis, and immune regulation. The CXorf48 gene encodes a protein with a conserved domain structure, including a putative signal peptide and transmembrane regions, implying possible secretion or membrane-associated functions. Its expression has been detected in various tissues, with elevated levels observed in certain cancers, hinting at a potential link to tumorigenesis or cancer progression.
Recombinant human CXorf48 protein is typically produced using heterologous expression systems (e.g., bacteria, mammalian cells) for functional studies. This engineered approach enables large-scale production of purified protein for investigating its biochemical properties, interactome, and signaling mechanisms. Recent reports highlight its interaction with proteins involved in DNA repair pathways and immune response modulation, suggesting dual roles in maintaining genomic stability and regulating inflammatory processes. Notably, abnormal CXorf48 expression has been correlated with clinical outcomes in colorectal, hepatocellular, and breast cancers, fueling interest in its utility as a diagnostic biomarker or therapeutic target.
Despite progress, challenges persist in fully delineating its physiological relevance, tissue-specific isoforms, and post-translational modifications. Ongoing research aims to clarify its contribution to X chromosome-related disease mechanisms and exploit its therapeutic potential in oncology and autoimmune disorders.
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