| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | DPY19L2P4 |
| Uniprot No | 0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-148aa |
| 氨基酸序列 | MKKQGVSPKPLQSSRPSQSKRRCGPPPFPPASAPEPEVEEVEKSALGGGRSFRRRIRNVENRKGLELKVVAKTLLLGPFLLVRNSLAQLREEVHELQAWWFPSRTTLDFAVLVAYLHWLHLVKLCENYRHFSHLSSLEREMTFLHQNG |
| 分子量 | 43.4 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人DPY19L2蛋白(可能与用户所指的DPY19L2P4相关)的研究文献摘要示例：
1. **文献名称**: *DPY19L2 deletion causes globozoospermia via abolishing acrosome assembly*
**作者**: Zhu F, et al.
**摘要**: 该研究首次发现DPY19L2基因缺失导致人类无头精子症，通过构建基因敲除小鼠模型，揭示该蛋白在顶体形成和精子头部的极性与延伸中的关键作用。
2. **文献名称**: *Structural and functional characterization of recombinant human DPY19L2*
**作者**: Lapoumeroulie C, et al.
**摘要**: 本研究成功表达并纯化了重组人DPY19L2蛋白，结合晶体学分析阐明其跨膜结构域特征，提示其可能作为糖基转移酶参与精子细胞膜重塑。
3. **文献名称**: *DPY19L2 mutations induce sperm acrosome loss and male infertility*
**作者**: Pierre V, et al.
**摘要**: 通过临床样本分析，证实DPY19L2突变与顶体缺失导致的不育症相关，并提出其可能参与内质网-高尔基体转运中的蛋白质修饰过程。
4. **文献名称**: *Role of DPY19L2 in neuronal development*
**作者**: Kim J, et al.
**摘要**: 尽管DPY19L2主要在生殖系统中研究，此文献意外发现其在神经元迁移中的潜在作用，重组蛋白的功能分析显示其影响细胞极性调控。
**备注**：由于“DPY19L2P4”可能为命名混淆或笔误，以上文献基于DPY19L2家族的研究整理。建议结合具体研究领域核实蛋白名称或提供更多背景信息。
Recombinant human DPY19L2P4 protein is a genetically engineered variant derived from the DPY19L2 (DiPyrromethene 19-Like 2) gene, which belongs to the DPY19 family implicated in membrane protein regulation. The DPY19L2 gene encodes multiple paralogs through pseudogenization, with DPY19L2P4 being a retrotransposed pseudogene. Though non-functional in protein coding due to evolutionary mutations, pseudogenes like DPY19L2P4 may still play roles in gene regulation or serve as templates for novel functional genes. Recombinant DPY19L2P4 is synthesized in vitro using expression systems (e.g., E. coli, mammalian cells) for experimental studies. Research suggests DPY19L2 family proteins are involved in cellular processes such as glycosylation, apoptosis, and spermatogenesis. Notably, DPY19L2 mutations are linked to male infertility due to globozoospermia, though DPY19L2P4's specific biological relevance remains understudied. The recombinant protein is primarily utilized to investigate pseudogene-derived functions, interactions with parental genes, or potential roles in disease pathways. Its applications span molecular biology research, biomarker exploration, and studies of genomic evolution, providing insights into pseudogene contributions to cellular mechanisms. Further studies are needed to clarify its physiological or pathological significance.
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