关键信息
-
基因名
PALM2
- 应用
-
别名
PALM2Paralemmin-2
-
种属
Human
-
表达系统
E. coli
-
标签
His tag N-Terminus
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q8IXS6
-
表达区间
1-376 aa
-
氨基酸序列
MEMAEAELHK ERLQAIAEKR KRQTEIEGKR QQLDEQILLL QHSKSKVLRE KWLLQGIPAG TAEEEEARRR QSEEDEFRVK QLEDNIQRLE QEIQTLESEE SQISAKEQII LEKLKETEKS FKDFQKGFSS TDGAVYAMEI NVEKDKQTGE TKILSTSTIG PEGVHQKGVK VYDDGTKVVY EVRSGGTVVE NGVHKLSTKD VEELIQKAGQ SSLGGGHVSE RTVIADGSLS HPKEHMLCKE AKLEMVHKSR KDHSSGNPGQ QAQAPSAAGP EANLDQPVTM IFMGYQNIED EEETKKVLGY DETIKAELVL IDEDDEKSLR EKTVTDVSTI DGNAAELVSG RPVSDTTEPS SPEGKEESLA TEPAPGTQKK KRCQCC
-
分子量
122.0 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
PALM2, a member of the PALM (Proteins Associated with Localization and Memory) family, has garnered considerable attention in the field of molecular biology due to its crucial role in cell signaling and memory processes. Research has highlighted its involvement in various cellular functions, including synaptic plasticity, which is essential for learning and memory in the brain. Studies have shown that dysregulation of PALM2 may be linked to neurodegenerative diseases and cognitive impairments, sparking interest in understanding its molecular mechanisms. The recombinant expression of PALM2 protein allows researchers to investigate its structure-function relationship and interactions with other cellular proteins. Moreover, the use of recombinant PALM2 offers opportunities for developing potential therapeutic strategies by targeting its pathways. Given the significance of PALM2 in neuronal health, the characterization of this protein through techniques such as crystallography and electron microscopy is critical for elucidating its role in neurobiology and its potential as a biomarker or therapeutic target. Overall, research on PALM2 emphasizes the need for a deeper understanding of its functions and the implications of its dysregulation in health and disease.
