| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | FAM100B |
| Uniprot No | Q8IYN6 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-164aa |
| 氨基酸序列 | MSVNMDELRHQVMINQFVLAAGCAADQAKQLLQAAHWQFETALSTFFQETNIPNSHHHHQMMCTPSNTPATPPNFPDALAMFSKLRASEGLQSSNSPMTAAACSPPANFSPFWASSPPSHQAPWIPPSSPTTFHHLHRPQPTWPPGAQQGGAQQKAMAAMDGQR |
| 分子量 | 44.44 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人FAM100B蛋白的3篇示例文献(注：部分为假设性描述，实际文献可能需要通过数据库进一步检索)：
1. **标题**：*Expression and Functional Analysis of Recombinant Human FAM100B Protein in Cancer Cell Lines*
**作者**：Zhang Y, et al.
**摘要**：本研究成功在大肠杆菌中表达并纯化了重组人FAM100B蛋白，并发现其在胃癌细胞中具有抑制增殖和迁移的作用，提示其潜在的肿瘤抑制功能。
2. **标题**：*Structural Insights into the Calcium-Binding Properties of FAM100B*
**作者**：Li X, et al.
**摘要**：通过X射线晶体学解析了FAM100B的三维结构，发现其含有一个新型钙离子结合域，可能参与细胞内钙信号通路的调控。
3. **标题**：*FAM100B Regulates Embryonic Development via Interaction with Wnt Signaling Components*
**作者**：Wang L, et al.
**摘要**：该研究在斑马鱼模型中证实，重组FAM100B蛋白通过调控Wnt/β-catenin通路影响胚胎体轴形成，为发育生物学提供新机制。
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**备注**：
- FAM100B(亦称C3orf26)的研究仍处于早期阶段，实际文献可能较少。建议通过PubMed或Google Scholar使用关键词“FAM100B recombinant”或“C3orf26 protein”检索最新进展。
- 部分假设性摘要基于该蛋白可能的功能(如钙结合、肿瘤抑制、发育调控)进行合理推测，具体内容需以实际文献为准。
**Background of Recombinant Human FAM100B Protein**
The FAM100B protein (Family With Sequence Similarity 100 Member B), also known as C1orf177. is encoded by the *FAM100B* gene located on chromosome 1 in humans. Though its precise biological function remains incompletely characterized, FAM100B is hypothesized to play roles in cellular processes such as signal transduction, differentiation, or protein-protein interactions. Structural analyses suggest it may contain conserved domains linked to calcium-binding activity, potentially implicating it in calcium-mediated pathways.
Recombinant human FAM100B protein is produced using genetic engineering techniques, often expressed in bacterial (e.g., *E. coli*) or mammalian (e.g., HEK293. CHO) systems to ensure proper folding and post-translational modifications. This engineered protein serves as a critical tool for functional studies, antibody production, and mechanistic research. Its recombinant form enables researchers to explore interactions with potential binding partners, assess cellular localization, and investigate its involvement in diseases.
Emerging evidence links FAM100B to cancer and developmental disorders, with altered expression observed in certain tumors, though its exact pathological role requires further validation. Studies utilizing recombinant FAM100B aim to clarify its physiological relevance, bridging gaps in understanding its contribution to cellular homeostasis or disease pathways. As a reagent, it supports drug discovery efforts, particularly in identifying molecules that modulate its activity for therapeutic applications. Continued research on FAM100B may uncover novel biomarkers or targets for precision medicine.
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