Recombinant Human FAM71F1 Protein

Here’s a concise overview of recombinant human FAM71F1 protein:

The FAM71F1 (Family with Sequence Similarity 71 Member F1) gene encodes a poorly characterized protein predominantly expressed in human testicular tissues, suggesting potential roles in male reproductive biology. First identified through genomic screening, FAM71F1 belongs to a multi-gene family with conserved domains across species, though its exact physiological functions remain unclear. Studies indicate its testis-specific expression pattern, particularly in spermatogenic cells, linking it to spermatogenesis or sperm maturation processes. Structural predictions reveal a globular protein with potential post-translational modification sites, though experimental validation is limited.

Recombinant FAM71F1 protein is artificially produced using expression systems (e.g., *E. coli* or mammalian cells) for functional studies. This engineered version enables researchers to investigate its biochemical properties, interaction partners, and potential involvement in fertility-related pathways. Current research focuses on clarifying its molecular mechanisms, with hypotheses proposing roles in sperm motility regulation or acrosome formation. However, its enzymatic activity (if any) and regulatory networks are undefined. Interest in FAM71F1 also extends to reproductive medicine, as aberrant expression patterns have been observed in male infertility cases. Technical challenges persist in characterizing this protein due to its low natural abundance and structural complexity, driving the need for recombinant forms to advance diagnostic or therapeutic explorations in reproductive health. Further studies are required to map its 3D structure and validate in vivo functions.