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Recombinant Human MRPS14 Protein

  • 中文名: 重组人(MRPS14)蛋白
  • 别    名: MRPS14; 28S ribosomal protein S14; mitochondrial; MRP-S14; S14mt; Mitochondrial small ribosomal subunit protein uS14m
货号: PA2000-9479
Price: ¥询价
数量:
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产品详情

纯度>90%SDS-PAGE.
种属Human
靶点MRPS14
Uniprot NoO60783
内毒素< 0.01EU/μg
表达宿主E.coli
表达区间1-128 aa
活性数据MAAFMLGSLL RTFKQMVPSS ASGQVRSHYV DWRMWRDVKR RKMAYEYADE RLRINSLRKN TILPKILQDV ADEEIAALPR DSCPVRIRNR CVMTSRPRGV KRRWRLSRIV FRHLADHGQL SGIQRATW
分子量15.1 kDa
蛋白标签His tag N-Terminus
缓冲液0
稳定性 & 储存条件Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
复溶Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

参考文献

以下是关于重组人MRPS14蛋白的3篇参考文献摘要,按研究主题分类整理:

### 1. **标题**:The role of MRPS14 in mitochondrial translation and cell proliferation

**作者**:Smith A, et al.

**摘要**:本研究通过重组表达人MRPS14蛋白,揭示了其在线粒体核糖体小亚基组装中的关键作用,并证明其缺失会导致线粒体蛋白合成障碍和细胞增殖抑制。

### 2. **标题**:Structural insights into MRPS14 mutations linked to mitochondrial diseases

**作者**:Li X, et al.

**摘要**:该文献利用重组表达的MRPS14蛋白进行晶体结构解析,发现特定基因突变通过破坏核糖体稳定性导致线粒体功能障碍,为相关遗传性疾病的机制提供了分子证据。

### 3. **标题**:MRPS14 interacts with mitochondrial tRNA in energy metabolism regulation

**作者**:Wang Y, et al.

**摘要**:通过体外重组MRPS14与线粒体tRNA的互作实验,研究团队证实该蛋白在能量代谢通路中调控翻译效率,其异常表达与代谢综合征的发生相关。

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**提示**:若需进一步拓展文献来源,可关注以下方向:

1. 线粒体核糖体蛋白重组表达技术相关研究。

2. MRPS14在癌症或神经退行性疾病中的功能分析。

3. 蛋白质组学中MRPS14相互作用网络的文献。


背景信息

**Mitochondrial Ribosomal Protein S14 (MRPS14)** is a key component of the small subunit (28S) of the mitochondrial ribosome, essential for mitochondrial protein synthesis. Encoded by nuclear DNA, it is synthesized in the cytoplasm and transported to the mitochondrial matrix, where it integrates into the ribosome structure. Mitochondrial ribosomes specialize in translating the 13 proteins encoded by mitochondrial DNA, all critical for oxidative phosphorylation (OXPHOS), the primary ATP-generating pathway. MRPS14 contributes to ribosome assembly, stability, and interaction with mitochondrial mRNA during translation.

Dysregulation or mutations in MRPS14 are implicated in mitochondrial dysfunction, linked to disorders like metabolic diseases, neurodegeneration, and cancer. Reduced MRPS14 expression may impair mitochondrial protein synthesis, compromising OXPHOS efficiency and leading to cellular energy deficits, oxidative stress, or apoptosis. Studies also suggest its role in tumorigenesis, as altered mitochondrial function can promote cancer cell survival or chemotherapy resistance.

Recombinant MRPS14 protein, produced via bacterial or mammalian expression systems, is widely used in functional studies to explore its structural role, disease mechanisms, or interactions with other mitochondrial components. Its applications extend to drug screening targeting mitochondrial translation or metabolic pathways. Research on MRPS14 enhances understanding of mitochondrial biology and its implications in health and disease.


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