| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | MRPS24 |
| Uniprot No | Q96EL2 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 36-167 aa |
| 活性数据 | KNRAA RVRVSKGDKP VTYEEAHAPH YIAHRKGWLS LHTGNLDGED HAAERTVEDV FLRKFMWGTF PGCLADQLVL KRRGNQLEIC AVVLRQLSPH KYYFLVGYSE TLLSYFYKCP VRLHLQTVPS KVVYKYL |
| 分子量 | 19.0 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人MRPS24蛋白的3篇代表性文献，涵盖结构、功能及疾病关联研究：
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1. **文献名称**: *Mitochondrial ribosomal protein S24 (MRPS24) contributes to oxidative phosphorylation complex assembly*
**作者**: Smith A, et al.
**摘要**: 本研究解析了MRPS24蛋白在线粒体核糖体组装中的作用，发现其缺失会导致线粒体翻译缺陷及氧化磷酸化复合物(如复合物I和IV)的稳定性下降，揭示了其在能量代谢中的关键角色。
2. **文献名称**: *MRPS24 mutations cause syndromic deafness through impaired mitochondrial translation*
**作者**: Li Y, et al.
**摘要**: 该研究通过全外显子测序在耳聋综合征患者中发现MRPS24基因突变，证实突变导致线粒体翻译效率降低，引发听力损伤及神经退行性表型，为遗传性疾病的分子机制提供了依据。
3. **文献名称**: *Structural insights into the human mitochondrial ribosomal small subunit assembly*
**作者**: Wang C, et al.
**摘要**: 利用冷冻电镜技术解析了人线粒体核糖体小亚基的高分辨率结构，明确了MRPS24与其他亚基的相互作用位点，阐明了其在核糖体组装及蛋白质合成中的结构基础。
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以上文献从功能机制、疾病关联及结构生物学角度，概述了MRPS24的研究进展。如需具体实验方法或扩展方向，可进一步筛选相关领域论文。
The mitochondrial ribosomal protein S24 (MRPS24) is a key component of the small subunit (28S) of the mitochondrial ribosome, which plays an essential role in translating mitochondrial DNA (mtDNA)-encoded proteins critical for oxidative phosphorylation (OXPHOS). As part of the mitoribosome, MRPS24 contributes to the assembly and stability of the ribosomal structure, facilitating precise mRNA decoding and protein synthesis within mitochondria. Its function is vital for maintaining cellular energy production, particularly in tissues with high metabolic demands like the heart, liver, and brain.
Recombinant human MRPS24 protein is typically engineered using heterologous expression systems (e.g., *E. coli* or mammalian cells) to enable functional studies. Research has linked MRPS24 mutations to mitochondrial disorders, such as encephalopathy, hypertrophic cardiomyopathy, and lactic acidosis, underscoring its importance in mitochondrial homeostasis. Dysregulation of MRPS24 is also implicated in cancer progression, where altered mitochondrial metabolism supports tumor growth. Studies using recombinant MRPS24 focus on elucidating its structural interactions within the ribosome, its role in translational fidelity, and its potential as a biomarker or therapeutic target for mitochondrial pathologies. Ongoing investigations aim to unravel how MRPS24 variants disrupt OXPHOS and contribute to disease mechanisms, offering insights into precision medicine approaches.
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