| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | MS4A2 |
| Uniprot No | Q01362 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-244 aa |
| 活性数据 | MDTESNRRANLALPQEPSSVPAFEVLEISPQEVSSGRLLKSASSPPLHTWLTVLKKEQEFLGVTQILTAMICLCFGTVVCSVLDISHIEGDIFSSFKAGYPFWGAIFFSISGMLSIISERRNATYLVRGSLGANTASSIAGGTGITILIINLKKSLAYIHIHSCQKFFETKCFMASFSTEIVVMMLFLTILGLGSAVSLTICGAGEELKGNKVPEDRVYEELNIYSATYSELEDPGEMSPPIDL |
| 分子量 | 52.9 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人MS4A2蛋白的3篇参考文献示例(注：内容为虚构示例，仅供参考)：
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1. **文献名称**：*Cloning and Functional Characterization of Recombinant Human MS4A2 in Mast Cell Signaling*
**作者**：Kimura T, et al.
**摘要**：该研究成功在大肠杆菌和哺乳动物细胞中表达重组人MS4A2蛋白，证实其与FcεRIα亚基形成复合物，并参与肥大细胞中IgE介导的过敏信号传导。研究通过体外实验表明，MS4A2缺陷会显著降低组胺释放水平。
2. **文献名称**：*Structural Insights into MS4A2 via Cryo-EM: Implications for IgE Receptor Assembly*
**作者**：Zhang L, et al.
**摘要**：利用冷冻电镜技术解析了重组人MS4A2蛋白在FcεRI受体复合物中的三维结构，揭示了其跨膜区相互作用的关键氨基酸残基，为开发靶向过敏性疾病的小分子抑制剂提供结构基础。
3. **文献名称**：*MS4A2 Gene Variants and Recombinant Protein Expression in Allergic Asthma*
**作者**：Gupta S, et al.
**摘要**：通过表达重组MS4A2蛋白，分析了不同基因突变对蛋白稳定性的影响，发现某些突变导致其与γ亚基结合能力下降，可能与哮喘患者的过敏反应增强相关。
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示例中研究涵盖了重组表达、结构功能及疾病关联，供参考使用。实际文献需通过学术数据库检索。
MS4A2 (Membrane-Spanning 4-Domains A2), also known as FcεRIβ or β-chain of the high-affinity IgE receptor, is a member of the MS4A protein family characterized by conserved transmembrane domains. It is primarily expressed in immune cells, particularly mast cells and basophils, where it plays a critical role in immunoglobulin E (IgE)-mediated allergic responses. Structurally, MS4A2 is a four-transmembrane protein that stabilizes the FcεRI receptor complex, facilitating signal transduction upon allergen binding. This activation triggers the release of inflammatory mediators like histamine, contributing to hypersensitivity reactions.
Genetically, MS4A2 is located on chromosome 11q12. and polymorphisms in this gene have been linked to increased susceptibility to asthma, allergic rhinitis, and atopic dermatitis. Beyond allergies, emerging studies suggest its involvement in certain cancers and autoimmune disorders, though mechanisms remain under investigation. Recombinant human MS4A2 protein is commonly produced in mammalian or bacterial expression systems for functional studies, antibody development, or drug screening. Its applications extend to elucidating IgE-mediated pathways and designing therapeutic strategies targeting allergic diseases. Current research also explores its regulatory interactions with other signaling molecules, highlighting its potential as a biomarker or therapeutic target.
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