关键信息
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基因名
KLK1
- 应用
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别名
KLK1；Kallikrein-1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P06870
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表达区间
25-262aa
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氨基酸序列
IVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWVLTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHDLMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKILPNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNKPSVAVRVLSYVKWIEDTIAENS
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分子量
42.4kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
KLK1, or Kallikrein-related peptidase 1, is a member of the kallikrein family of serine proteases known for its role in various physiological processes, including blood pressure regulation, reproductive functions, and the modulation of inflammatory responses. Research into KLK1 has gained momentum due to its emerging importance in the diagnosis and therapeutic targeting of diseases, particularly cancer and cardiovascular disorders. Elevated levels of KLK1 have been associated with poor prognosis in several malignancies, suggesting its potential as a biomarker for early detection and monitoring of tumor progression. Additionally, KLK1 is being investigated for its role in the renin-angiotensin system, which is critical for maintaining vascular homeostasis. With advances in recombinant DNA technology, producing KLK1 in a recombinant form has become feasible, enabling detailed studies of its structure-function relationships, enzymatic activity, and interaction with specific substrates or inhibitors. This research not only enhances our understanding of KLK1's biological roles but also paves the way for the development of KLK1-based diagnostic tools and therapeutic agents. Overall, the study of KLK1 recombinant protein is vital to unraveling its clinical significance and exploring its potential applications in precision medicine.
