| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | MSS51 |
| Uniprot No | Q4VC12 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-460 aa |
| 活性数据 | MAPRSRRRRHKKPPSSVAPIIMAPTTIVTPVPLTPSKPGPSIDTLGFFSLDDNVPGLSQLILQKLNMKSYEEYKLVVDGGTPVSGFGFRCPQEMFQRMEDTFRFCAHCRALPSGLSDSKVLRHCKRCRNVYYCGPECQKSDWPAHRRVCQELRLVAVDRLMEWLLVTGDFVLPSGPWPWPPEAVQDWDSWFSMKGLHLDATLDAVLVSHAVTTLWASVGRPRPDPDVLQGSLKRLLTDVLSRPLTLGLGLRALGIDVRRTGGSTVHVVGASHVETFLTRPGDYDELGYMFPGHLGLRVVMVGVDVATGFSQSTSTSPLEPGTIQLSAHRGLYHDFWEEQVETGQTHHPDLVAAFHPGFHSSPDLMEAWLPTLLLLRDYKIPTLITVYSHQELVSSLQILVELDTHITAVGSNPFMSLKPEQVYSSPNKQPVYCSAYYIMFLGSSCQLDNRQLEEKVDGGI |
| 分子量 | 77.6 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人MSP51蛋白的参考文献示例(注：MSP51并非广泛研究的蛋白名称，可能与实际研究存在差异，以下内容为假设性描述)：
1. **文献名称**：**"Expression and Functional Characterization of Recombinant Human MSP51 in Escherichia coli"**
**作者**：Chen L, et al.
**摘要**：该研究成功构建了大肠杆菌表达系统生产重组人MSP51蛋白，通过优化诱导条件提高了蛋白溶解度，并证实其在体外具有促进巨噬细胞迁移的能力。
2. **文献名称**：**"Structural Insights into MSP51-mediated Immune Regulation"**
**作者**：Wang Y, Zhang K.
**摘要**：利用X射线晶体学解析了MSP51的三维结构，发现其与趋化因子受体CXCR4的相互作用域，揭示了其在炎症反应中的潜在调控机制。
3. **文献名称**：**"MSP51 as a Novel Biomarker in Autoimmune Diseases"**
**作者**：Gupta S, et al.
**摘要**：通过ELISA检测类风湿性关节炎患者血清中MSP51水平显著升高，提示其可能作为自身免疫疾病的诊断标志物或治疗靶点。
4. **文献名称**：**"Recombinant MSP51 Enhances Tissue Repair in Murine Models of Colitis"**
**作者**：Tanaka H, et al.
**摘要**：在结肠炎小鼠模型中，重组MSP51通过激活肠道上皮细胞STAT3信号通路，显著减轻炎症并促进黏膜再生。
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**备注**：若"MSP51"具体指代某特殊蛋白(如为笔误或非标准缩写)，建议进一步确认名称或补充背景信息以便提供更精准的文献资料。
**Background of Recombinant Human MSS51 Protein**
MSS51. a mitochondrial protein encoded by the nuclear genome, plays a critical role in mitochondrial gene expression and respiratory chain function. It is primarily involved in the assembly and stability of the cytochrome c oxidase (COX) complex, a key component of the mitochondrial electron transport chain (ETC) essential for aerobic ATP production. Studies suggest MSS51 acts as a translational activator or chaperone, regulating the synthesis or stability of mitochondrial-encoded COX subunits, particularly COX1. Dysregulation of MSS51 is linked to mitochondrial disorders characterized by COX deficiency, impacting cellular energy metabolism.
Recombinant human MSS51 protein is engineered using expression systems like *E. coli* or mammalian cells, enabling studies on its molecular interactions, structural features, and role in mitochondrial biogenesis. Its recombinant form facilitates research into diseases such as Leigh syndrome, myopathies, and neurodegenerative conditions. Additionally, MSS51 has garnered interest in cancer biology, as mitochondrial dysfunction is a hallmark of tumorigenesis. Researchers utilize this protein to explore therapeutic strategies targeting mitochondrial respiration or gene regulation pathways. Further studies aim to elucidate post-translational modifications and regulatory networks involving MSS51. enhancing our understanding of mitochondrial health and disease.
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