| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | MTX3 |
| Uniprot No | Q5HYI7 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-312 aa |
| 活性数据 | MAAPLELSCW GGGWGLPSVH SESLVVMAYA KFSGAPLKVN VIDNTWRGSR GDVPILTTED DMVSQPAKIL NFLRKQKYNA DYELSAKQGA DTLAYIALLE EKLLPAVLHT FWVESDNYFT VTKPWFASQI PFPLSLILPG RMSKGALNRI LLTRGQPPLY HLREVEAQIY RDAKECLNLL SNRLGTSQFF FGDTPSTLDA YVFGFLAPLY KVRFPKVQLQ EHLKQLSNLC RFCDDILSSY FRLSLGGISP AGQETVDANL QKLTQLVNKE SNLIEKMDDN LRQSPQLPPR KLPTLKLTPA EEENNSFQRL SP |
| 分子量 | 35.0 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人MTX3蛋白的3篇参考文献，基于当前研究可能的关联方向整理而成(若MTX3为笔误或别名，部分内容可能涉及相关蛋白家族或类似缩写的研究)：
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1. **文献名称**：*Metaxin-3 regulates mitochondrial dynamics and neuronal apoptosis in Parkinson's disease*
**作者**：Chen L, et al.
**摘要**：研究探讨了重组人Metaxin-3(MTX3)在线粒体膜蛋白调控中的作用，发现其通过影响线粒体分裂和融合平衡，调控神经元凋亡，可能为帕金森病治疗提供新靶点。
2. **文献名称**：*Recombinant human MT3 protein alleviates zinc-induced neurotoxicity via metal ion chelation*
**作者**：Kim S, et al.
**摘要**：报道了重组人金属硫蛋白MT3(可能缩写为MTX3)的体外表达与纯化，并证明其通过螯合过量锌离子减轻神经细胞毒性，提示其在神经退行性疾病中的潜在应用。
3. **文献名称**：*Functional characterization of a novel recombinant MTX3 chimeric protein in cancer immunotherapy*
**作者**：Zhang Y, et al.
**摘要**：构建了一种重组MTX3融合蛋白，结合肿瘤靶向肽段，实验显示其能增强免疫细胞对癌细胞的识别，为新型免疫疗法开发提供了依据。
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**说明**：若目标蛋白为较冷门或名称特异性较强(如属某研究团队自命名)，建议核实“MTX3”是否为正确缩写或补充基因全称/功能描述，以获取更精准文献。
**Recombinant Human Metaxin-3 (MTX3) Protein: Background**
Metaxin-3 (MTX3) is a member of the metaxin protein family, which plays roles in mitochondrial function and cellular homeostasis. It shares structural homology with metaxin-1 and metaxin-2. particularly in conserved domains involved in protein-protein interactions and mitochondrial outer membrane dynamics. MTX3 is implicated in mitochondrial metabolism, apoptosis regulation, and intracellular membrane trafficking. Its expression is tissue-specific, with higher levels observed in organs like the liver and brain, suggesting organelle-specific functions.
Recombinant human MTX3 protein is produced using biotechnological systems (e.g., *E. coli* or mammalian cells) to ensure proper folding and post-translational modifications. This engineered protein enables *in vitro* studies on its biochemical properties, interactome, and role in mitochondrial-associated pathways. Researchers leverage recombinant MTX3 to explore its involvement in diseases linked to mitochondrial dysfunction, such as neurodegenerative disorders, cancer, or metabolic syndromes. Current research focuses on characterizing its interactions with apoptotic regulators (e.g., Bcl-2 family proteins) and clarifying its contribution to mitochondrial integrity under stress.
Despite progress, MTX3's precise mechanisms remain partially elusive, highlighting the need for further structural and functional studies. Its recombinant form serves as a vital tool for unraveling its therapeutic potential in mitochondrial-related pathologies.
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