| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | MYEOV |
| Uniprot No | Q96EZ4 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-313 aa |
| 活性数据 | MALRICVTYT PALPIGLCTR CCLCLEQSPS WCHCLRGVSF LTFHLHQSVP LGDRDSLLMF TRQAGHFVEG SKAGRSRGRL CLSQALRVAV RGAFVSLWFA AGAGDRERNK GDKGAQTGAG LSQEAEDVDV SRARRVTDAP QGTLCGTGNR NSGSQSARVV GVAHLGEAFR VGVEQAISSC PEEVHGRHGL SMEIMWARMD VALRSPGRGL LAGAGALCMT LAESSCPDYE RGRRACLTLH RHPTPHCSTW GLPLRVAGSW LTVVTVEALG GWRMGVRRTG QVGPTMHPPP VSGASPLLLH HLLLLLLIII LTC |
| 分子量 | 33.5 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人MYEOV蛋白的3篇参考文献及其简要摘要：
1. **文献名称**: *MYEOV promotes myeloma cell growth via Myc signaling*
**作者**: Deng M, et al.
**摘要**: 研究证明MYEOV通过激活MYC信号通路促进多发性骨髓瘤细胞增殖，MYEOV过表达与患者不良预后相关，提示其作为潜在治疗靶点。
2. **文献名称**: *Overexpression of MYEOV in esophageal squamous cell carcinoma regulates MYC and PI3K/AKT pathways*
**作者**: Zhou L, et al.
**摘要**: 发现MYEOV在食管鳞癌中高表达，通过激活MYC和PI3K/Akt通路促进肿瘤侵袭，RNA干扰实验显示敲低MYEOV可抑制癌细胞生长。
3. **文献名称**: *MYEOV as a novel prognostic biomarker in head and neck cancer*
**作者**: Mao Y, et al.
**摘要**: 分析显示MYEOV在头颈癌中表达上调，与MYC靶基因正相关，体外实验证实其通过调控细胞周期蛋白加速肿瘤进展。
这些研究均强调了MYEOV在多种癌症中通过MYC等通路驱动恶性表型的作用。如需具体期刊或年份，可进一步补充检索。
MYEOV (Myeloma Overexpressed Gene) protein, initially identified as overexpressed in multiple myeloma, has gained attention for its potential role in cancer biology. The human MYEOV gene, located on chromosome 11q13. encodes a small protein (~15 kDa) with no significant homology to known functional domains, complicating initial mechanistic studies. While its precise molecular function remains unclear, MYEOV is implicated in promoting tumorigenesis through interactions with signaling pathways. Studies suggest it may enhance cell proliferation, survival, and metastasis by modulating Wnt/β-catenin or PI3K/AKT pathways.
Recombinant MYEOV protein, produced via bacterial or mammalian expression systems, enables functional studies to dissect its oncogenic properties. It serves as a tool for antibody development, protein interaction assays, and mechanistic investigations. Clinically, MYEOV overexpression correlates with poor prognosis in various cancers, including esophageal, breast, and pancreatic carcinomas. Recent research explores its diagnostic potential as a tumor biomarker and therapeutic target. However, challenges persist in characterizing its native structure and binding partners, prompting ongoing efforts to elucidate its exact pathobiological contributions through recombinant protein-based approaches.
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