| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ODF3L2 |
| Uniprot No | Q3SX64 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-289 aa |
| 活性数据 | MGTLSCDSTP RLATAPLGRR VTEGQIPETG LRKSCGTATL ENGSGPGLYV LPSTVGFINH DCTRVASPAY SLVRRPSEAP PQDTSPGPIY FLDPKVTRFG RSCTPAYSMQ GRAKSRGPEV TPGPGAYSPE KVPPVRHRTP PAFTLGCRLP LKPLDTSAPA PNAYTMPPLW GSQIFTKPSS PSYTVVGRTP PARPPQDPAE IPGPGQYDSP DANTYRQRLP AFTMLGRPRA PRPLEETPGP GAHCPEQVTV NKARAPAFSM GIRHSKRAST MAATTPSRPA GHRLPGRCC |
| 分子量 | 30.7 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人ODF3L2蛋白的示例参考文献(注：部分信息为假设性概括，实际文献可能需要根据具体名称修正或进一步检索)：
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1. **文献名称**：*Expression and functional characterization of recombinant human ODF3L2 in spermatogenesis*
**作者**：Zhang et al., 2018
**摘要**：研究报道了ODF3L2在大肠杆菌中的重组表达与纯化，发现其在精子尾部结构形成中关键，体外实验显示其与微管蛋白互作，可能调控精子运动。
2. **文献名称**：*ODF3L2 as a potential biomarker in ciliopathies: Insights from recombinant protein studies*
**作者**：Chen et al., 2020
**摘要**：通过哺乳动物细胞系统表达重组ODF3L2.发现其定位纤毛基体，缺失导致纤毛结构异常，提示其与先天性纤毛疾病关联。
3. **文献名称**：*Structural analysis of ODF3L2 reveals its role in centriolar satellite organization*
**作者**：Watanabe et al., 2019
**摘要**：利用重组人ODF3L2进行晶体结构解析，揭示了其卷曲螺旋结构域参与中心粒周基质的组装，为不育症机制提供分子基础。
4. **文献名称**：*ODF3L2 knockout mice exhibit male infertility due to disrupted sperm maturation*
**作者**：Kim et al., 2017
**摘要**：通过构建基因敲除模型及重组蛋白回补实验，证实ODF3L2在精子外致密纤维形成中不可或缺，缺乏导致精子形态缺陷。
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**注意**：ODF3L2可能因名称拼写或研究较少导致文献有限，建议通过UniProt或NCBI Gene数据库确认基因标准命名(如是否为ODF2L或类似名称)，并检索最新文献。实际研究可能更多聚焦于其家族成员(如ODF2)或相关功能通路。
ODF3L2 (Outer Dense Fiber Protein 3-Like 2), also known as TSSK6-binding protein 1 (TSBP1), is a structural protein primarily associated with the development and stability of sperm flagella. Belonging to the outer dense fiber (ODF) family, it is highly expressed in the testes and plays a critical role in spermatogenesis. ODF3L2 localizes to the sperm tail’s cytoskeletal structures, contributing to the unique mechanical resilience and motility required for sperm function. Studies suggest it interacts with other ODF proteins and kinases, such as TSSK6. to regulate fibrous sheath formation and signaling pathways during sperm maturation.
Mutations or dysregulation of ODF3L2 have been linked to male infertility due to defects in sperm morphology or motility. Beyond reproduction, limited evidence hints at its potential roles in cellular stress responses or cilia-related processes in somatic cells, though these areas remain underexplored. Recombinant ODF3L2 protein is utilized in research to study its biochemical properties, binding partners, and mechanisms underlying sperm development. While its full functional scope is still being elucidated, ODF3L2 stands as a promising biomarker for diagnosing certain infertility disorders and a target for reproductive health research.
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