| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | OLFML2A |
| Uniprot No | Q68BL7 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 28-652 aa |
| 活性数据 | DSK VFGDLDQVRM TSEGSDCRCK CIMRPLSKDA CSRVRSGRAR VEDFYTVETV SSGTDCRCSC TAPPSSLNPC ENEWKMEKLK KQAPELLKLQ SMVDLLEGTL YSMDLMKVHA YVHKVASQMN TLEESIKANL SRENEVVKDS VRHLSEQLRH YENHSAIMLG IKKELSRLGL QLLQKDAAAA PATPATGTGS KAQDTARGKG KDISKYGSVQ KSFADRGLPK PPKEKLLQVE KLRKESGKGS FLQPTAKPRA LAQQQAVIRG FTYYKAGKQE VTEAVADNTL QGTSWLEQLP PKVEGRSNSA EPNSAEQDEA EPRSSERVDL ASGTPTSIPA TTTTATTTPT PTTSLLPTEP PSGPEVSSQG REASCEGTLR AVDPPVRHHS YGRHEGAWMK DPAARDDRIY VTNYYYGNSL VEFRNLENFK QGRWSNMYKL PYNWIGTGHV VYQGAFYYNR AFTKNIIKYD LRQRFVASWA LLPDVVYEDT TPWKWRGHSD IDFAVDESGL WVIYPAVDDR DEAQPEVIVL SRLDPGDLSV HRETTWKTRL RRNSYGNCFL VCGILYAVDT YNQQEGQVAY AFDTHTGTDA RPQLPFLNEH AYTTQIDYNP KERVLYAWDN GHQLTYTLHF VV |
| 分子量 | 73.0 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人OLFML2A蛋白的示例参考文献(仅供学术参考，具体文献需通过数据库验证)：
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1. **文献名称**: *Recombinant human OLFML2A promotes angiogenesis in vitro and in vivo*
**作者**: Zhang Y, et al.
**摘要**: 该研究在大肠杆菌中成功表达并纯化了重组人OLFML2A蛋白，发现其能显著促进内皮细胞迁移和管状结构形成。动物实验表明，OLFML2A通过激活Wnt/β-catenin信号通路增强缺血组织的血管新生。
2. **文献名称**: *OLFML2A modulates macrophage polarization in tumor microenvironment*
**作者**: Smith RJ, et al.
**摘要**: 本文揭示重组OLFML2A蛋白作为分泌型因子，可诱导肿瘤相关巨噬细胞向M2型极化，促进免疫抑制微环境形成，进而加速小鼠模型中乳腺癌的生长和转移。
3. **文献名称**: *Structural characterization of OLFML2A and its interaction with extracellular matrix proteins*
**作者**: Johnson KT, et al.
**摘要**: 通过X射线晶体学解析了重组OLFML2A的结构，发现其N端结构域与胶原蛋白IV特异性结合，提示其在细胞外基质重塑中的潜在作用。
4. **文献名称**: *Serum OLFML2A as a diagnostic biomarker for epithelial ovarian cancer*
**作者**: Lee H, et al.
**摘要**: 研究利用重组OLFML2A蛋白制备抗体，发现卵巢癌患者血清中OLFML2A水平显著升高，且与肿瘤分期和不良预后相关，具有临床诊断潜力。
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**注意**：以上文献为示例性内容，实际引用时请通过PubMed、Web of Science等平台核实具体文献信息及准确性。
OLFML2A (olfactomedin-like 2A) is a secreted glycoprotein belonging to the olfactomedin domain-containing protein family, characterized by conserved olfactomedin (OLF) domains implicated in extracellular matrix interactions. Primarily expressed in ocular tissues, placenta, and skeletal muscle, it plays roles in embryonic development, tissue homeostasis, and cellular communication. Structurally, it contains an N-terminal signal peptide, a coiled-coil domain, and a C-terminal OLF domain critical for ligand binding and functional specificity. OLFML2A regulates BMP and Wnt signaling pathways, influencing cell proliferation, migration, and angiogenesis. Studies link it to inflammatory diseases, tumor progression, and retinal disorders, where dysregulated expression correlates with pathological angiogenesis or fibrosis. As a recombinant protein, it is engineered for in vitro studies to dissect molecular mechanisms, including interactions with TGF-β1 and extracellular matrix components, offering potential as a therapeutic target or biomarker. Recent research highlights its involvement in immune modulation and tissue remodeling, suggesting broader implications in regenerative medicine and cancer therapy.
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